Sökning: "notch"

Visar resultat 6 - 10 av 189 avhandlingar innehållade ordet notch.

  1. 6. Diversification of TGF-β Signaling in Homeostasis and Disease

    Författare :Michael Vanlandewijck; Aristidis Moustakas; Carl-Henrik Heldin; Steven Dooley; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-β; signaling; SIK; EMT; polarity; Notch; ALK5; p21; growth arrest; Smurf; Smad7; receptor; SNF1LK; Molecular biology; Molekylärbiologi; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : With the dawn of metazoans, the ability of cells to communicate with each other became of paramount importance in maintaining tissue homeostasis. The transforming growth factor β (TGF-β) signaling pathway, which plays important roles during embryogenesis and in the adult organism, signals via a heterodimeric receptor complex consisting of two type II and two type I receptors. LÄS MER

  3. 7. FGFs and Wnts in pancreatic growth and β-cell function

    Författare :Stella Papadopoulou; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Wnt; FGF; pancreas; Notch; signal transduction; development; proliferation; progenitors; β-cells; feedback; GSIS; diabetes; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : Mesenchymal-epithelial interactions are pivotal for proper pancreatic growth and development. The pancreatic progenitor cells present in the early pancreatic anlagen proliferate and eventually give rise to all pancreatic cell types. LÄS MER

  4. 8. Oncogenic Pathways and Molecular Prognostics in Neuroblastoma

    Författare :Kristoffer von Stedingk; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Prognostics; Telomerase; snoRNP; miR-17-92; TGF-β; Notch; Hypoxia; Angiogenesis;

    Sammanfattning : Neuroblastoma is an embryonal malignancy that accounts for 15% of all cancer related deaths amongst children. Although the overall survival of patients has been improving over the last decades, the high-risk neuroblastoma patients have a survival rate of ... LÄS MER

  5. 9. TRAF6 stimulates TGFβ-induced oncogenic signal transduction in cancer cells

    Författare :Shyam Kumar Gudey; Marene Landström; Urban Lendahl; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; c-Jun; invasion; non-Smad; Notch; NICD; oncogenesis; presenilin1; PKCζ; prostate cancer; p21; p38; p300; Snail1; TGFβ; TβRI; TACE; TRAF6; ubiquitination; TGFbeta signal transduction; Pathology; patologi;

    Sammanfattning : Prostate cancer is one of the leading causes of cancer-related deaths in men worldwide, with 10,000 new cases/year diagnosed in Sweden. In this context, there is an urgent need to identify new biomarkers to detect prostate cancer at an initial stage for earlier treatment intervention. LÄS MER

  7. 10. Early development of the olfactory placode and early rostrocaudal patterning of the caudal neural tube

    Författare :Esther Maier; Lena Gunhaga; Fernando Giraldez; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; olfactory placode; caudal neural tube; Wnt; FGF; RA; BMP; Notch; patterning; Developmental biology; Utvecklingsbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The development of the nervous system is a complex process. Cell divisions, cell differentiation and signalling interactions must be tightly regulated. To comprehend the mature nervous system, we have to understand its assembly during development. LÄS MER