Sökning: "oncogenesis"

Visar resultat 1 - 5 av 45 avhandlingar innehållade ordet oncogenesis.

  1. 1. TRAF6 stimulates TGFβ-induced oncogenic signal transduction in cancer cells

    Författare :Shyam Kumar Gudey; Marene Landström; Urban Lendahl; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; c-Jun; invasion; non-Smad; Notch; NICD; oncogenesis; presenilin1; PKCζ; prostate cancer; p21; p38; p300; Snail1; TGFβ; TβRI; TACE; TRAF6; ubiquitination; TGFbeta signal transduction; Pathology; patologi;

    Sammanfattning : Prostate cancer is one of the leading causes of cancer-related deaths in men worldwide, with 10,000 new cases/year diagnosed in Sweden. In this context, there is an urgent need to identify new biomarkers to detect prostate cancer at an initial stage for earlier treatment intervention. LÄS MER

  3. 2. TRAF6, a key regulator of TGFβ-induced oncogenesis in prostate cancer

    Författare :Reshma Sundar; Marene Landström; Carl-Henrik Heldin; Petra Knaus; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TβRI; TGFβ; TACE; TRAF6; PS1; PKCζ; TβRI-ICD; NICD; Smad; non-Smad; prostate cancer; Snail1; MMP; p300; p21; PAI1; ubiquitination; cleavage; ICD; invasion; HES1; signaling; patologi; Pathology;

    Sammanfattning : Prostate cancer is the most common cancer in men, with the incidence rapidly increasing in Europe over the past two decades. Reliable biomarkers for prostate cancer are currently unavailable. Thus, there is an urgent need for improved biomarkers to diagnose prostate cancer at an early stage and to determine the best treatment options. LÄS MER

  4. 3. Long non-coding RNAs and cellular interactions : investigating underlying mechanisms of oncogenesis

    Författare :Jason T Serviss; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is a leading cause of death worldwide with one in 8 men and one in 11 women dying from the disease (World Health Organization, 2018). Despite vast improvements in cancer diagnosis and therapy, the global cancer burden continues to rise in unison with population growth and longevity. LÄS MER

  5. 4. Aspects of platelet-derived growth factor and its receptors in normal growth and oncogenesis

    Författare :Karin Forsberg; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  7. 5. Epstein-Barr virus and genomic instability : a new look at the mechanisms of viral oncogenesis

    Författare :Siamak Akbari Kamranvar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :EBV;

    Sammanfattning : EBV is associated with a variety of lymphoid and epithelial malignancies but the mechanisms of oncogenesis are still not fully understood. The aim of the work described in this thesis was to assess whether induction of genomic instability, as defined by the accumulation of non-clonal genetic aberrations, could play a role in EBV oncogenesis and identify the viral protein(s) responsible for this phenotype. LÄS MER