Sökning: "notch"

Visar resultat 16 - 20 av 189 avhandlingar innehållade ordet notch.

  1. 16. Molecular diversity in the Notch receptor family

    Författare :Paul Beatus; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : We have studied the Notch family of transmembrane receptors, which play a crucial role in cell fate determination. The Notch signalling pathway represents a conserved mechanism to mediate signalling between adjacent, equivalent cells and to direct them to adopt different cell fates. LÄS MER

  3. 17. Roles of Notch signalling in early embryonic development

    Författare :Heather Main; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Metazoan embryonic development requires a complex interplay of morphological processes coordinated with self-renewal and differentiation to correctly specify and maintain body cell types in the correct location. Notch signalling is a metazoan specific arbiter of cell fate decision processes, known to control lateral inhibition and asymmetric cell division processes throughout the metazoa and in the development of all metazoan organs. LÄS MER

  4. 18. Notch signaling : from receptor cleavage to chromatin remodeling

    Författare :Kia Strömberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : One of the principal signaling mechanisms that control development of multicellular organisms is the Notch signaling pathway. The transmembrane Notch receptor, presented at the cell surface, interacts with ligand on neighbouring cells. LÄS MER

  5. 19. The role of Notch signaling in cancer and metastasis

    Författare :Anders P Mutvei; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Notch signaling pathway is an evolutionary conserved cell-to-cell communication pathway that regulates many important aspects in the development and tissue homeostasis of multicellular animals. It operates in a wide range of cellular contexts and dysregulated Notch signaling has been linked to a number of diseases, including cancer. LÄS MER

  7. 20. Notch sensitivity and bridging laws in glass mat composites

    Författare :Johan Lindhagen; Luleå tekniska universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Polymera konstruktionsmaterial; Polymeric Composite Materials;

    Sammanfattning : The fracture behaviour of polymeric random glass mat reinforced composites was investigated. Such materials exhibit very large damage zones with fibre bridging. The damage zone sizes are often comparable with the specimen dimensions, which precludes the use of linear elastic frac-ture mechanics (LEFM). LÄS MER