Sökning: "miR-17-92"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet miR-17-92.

  1. 1. TGF-B signaling in Neuroblastoma and Renal Cell Carcinoma

    Författare :Anna-Karin Boström; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Renal Cell Carcinoma; ATN; Regeneration; Notch; TGF-B; EMT; Neuroblastoma; MYCN; miR-17-92;

    Sammanfattning : The tubular cells of the adult kidney are normally mitotically quiescent, in stark contrast to the massive regenerative capacity of the injured renal epithelium. In Paper I we characterized a new cell population of progenitor cells using ALDH as a selection marker. LÄS MER

  3. 2. Oncogenic Pathways and Molecular Prognostics in Neuroblastoma

    Författare :Kristoffer von Stedingk; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Prognostics; Telomerase; snoRNP; miR-17-92; TGF-β; Notch; Hypoxia; Angiogenesis;

    Sammanfattning : Neuroblastoma is an embryonal malignancy that accounts for 15% of all cancer related deaths amongst children. Although the overall survival of patients has been improving over the last decades, the high-risk neuroblastoma patients have a survival rate of ... LÄS MER

  4. 3. Metabolism and neural differentiation in childhood neuroblastoma

    Författare :Ganna Oliynyk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuroblastoma is the most common and aggressive extracranial solid tumor during childhood. MYCN-amplification is found in approximately 25 % of all neuroblastoma cases, and is defined as high-risk disease. Development of novel therapeutic approaches focused on MYCN targeting are essential for increased survival these children. LÄS MER

  5. 4. MYC and MNT in transcriptional regulation and chromatin dynamics

    Författare :Therese Wahlström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The MYC proto-oncogene regulates several cellular processes including cell cycle progression, proliferation, apoptosis and differentiation. In normal cells, MYC expression is induced upon cell cycle entry and is thereafter expressed at low levels during proliferation. LÄS MER

  7. 5. Exploring the genome-wide impact of estrogen receptor alpha and estrogen receptor beta in breast and colon cancer cells

    Författare :Karin Edvardsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Estrogen signaling is involved in the development and progression of breast cancer and is implicated to be protective in colon cancer. Estrogenic actions are conveyed through transcriptional regulation by ligand stimulated estrogen receptors (ERα and ERβ). LÄS MER