Sökning: "progenitors"

Visar resultat 1 - 5 av 246 avhandlingar innehållade ordet progenitors.

  1. 1. Maintenance and Commitment of Hematopoietic Progenitors: Role of flt3, c-kit and c-mpl

    Författare :Ole Johan Borge; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; KL; hematopoiesis; FL; cytokines; B-cells; commitment; flt3; differentiation; Haematology; IL-7; c-kit; progenitors; Hematologi; stem cells; thrombopoietin; viability; extracellular fluids; extracellulära vätskor;

    Sammanfattning : The need for red blood cells to transport oxygen and CO2, blood platelets to stop bleedings, and neutrophils, macrophages, B- and T-cells for host defense, is a prerequisite for life. These mature blood cells have a limited life span and are thus constantly replenished by an enormous cell production (estimated to 1012 cells per day) which primarily takes place in the bone marrow (BM). LÄS MER

  3. 2. Directing stem cells and progenitors towards neuronal differentiation - implications for experimental therapies for Parkinson's disease

    Författare :Anke Brederlau; Göteborgs universitet; []
    Nyckelord :stem cells; Parkinson s disease; progenitors; BMP; ASK1; dopamine;

    Sammanfattning : The insight that stem- and progenitor-cells contribute to replacement of nerve cells in the adult central nervous system is the basis of modern therapies for structural brain repair. Their goal is to protect, support and stimulate endogenous stem cells in areas affected by disease and to replace lost cells by transplanting in vitro generated, tailored nerve cells. LÄS MER

  4. 3. Modulation of retinal progenitors : A bird’s-eye view of retinal regeneration and disease

    Författare :Dardan Konjusha; Finn Hallböök; Rusty Lansford; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Developmental neurobiology; Retinoblastoma; MYCN; Cone photoreceptor; Nolz1; Endothelin; Müller cells;

    Sammanfattning : The cell populations of the retina and their intricate organization provide us with one of the most important senses – vision. All retinal cell populations are derived from a common progenitor pool as a result of tight regulation of proliferation, differentiation, dedifferentiation, and programmed cell death. LÄS MER

  5. 4. Lymphatic Vascular Morphogenesis : From Progenitors to Functional Vessels

    Författare :Nina Daubel; Taija Mäkinen; Markus Affolter; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lymphatic vasculature; morphogenesis; lymphvasculogenesis; mesentery; lymphatic capillary;

    Sammanfattning : The lymphatic vasculature is an important part of the circulatory system and crucial for normal functioning and maintenance of tissues. Yet, our understanding of the processes underlying lymphatic development and homeostasis are surprisingly limited. LÄS MER

  7. 5. FGFs and Wnts in pancreatic growth and β-cell function

    Författare :Stella Papadopoulou; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Wnt; FGF; pancreas; Notch; signal transduction; development; proliferation; progenitors; β-cells; feedback; GSIS; diabetes; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : Mesenchymal-epithelial interactions are pivotal for proper pancreatic growth and development. The pancreatic progenitor cells present in the early pancreatic anlagen proliferate and eventually give rise to all pancreatic cell types. LÄS MER