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Visar resultat 11 - 15 av 175 avhandlingar som matchar ovanstående sökkriterier.

1. 11. Metal homeostasis as critical determinant for cellular fitness

   Författare :Jutta Diessl; Sabrina Büttner; Rajini Rao; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; metal homeostasis; manganese toxicity; coenzyme Q synthesis; mitochondrial respiration; calcineurin signaling; Pmr1; SPCA1; calcium; survival; caloric restriction; Parkinson’s disease models; proteotoxicity; Pep4; cathepsin D; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : Metals play a crucial role in cellular biology. Bulk and trace metals such as calcium and manganese regulate a plethora of cellular processes ranging from signaling and oxidative stress to proteostasis and energy metabolism. LÄS MER

3. 12. The RNA exosome and the maintenance of genome integrity

   Författare :Judit Domingo Prim; Neus Visa; Andrés Aguilera; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; EXOSC10; RRP6; DNA damage; diRNA; DDRNA; DNA end resection; homologous recombination; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : The RNA exosome is a ribonucleolytic complex that acts on different RNA substrates and plays important roles in RNA metabolism. In recent years, the synthesis and the processing of RNA have been directly linked to the integrity of the genome. LÄS MER

4. 13. Harnessing the immunoregulatory capacity of single-stranded oligonucleotides to modulate innate immunity

   Författare :Aleksandra Dondalska; Anna-Lena Spetz; Jenny Hallgren Martinsson; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; single-stranded oligonucleotides; Toll-like receptors; influenza; respiratory syncytial virus; dendritic cell; mast cell; virus infection; inflammation; itch; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : As the first line of defense, the innate immune system is exceptionally efficacious against invading pathogens but must be tightly regulated to avoid immune-related pathogenesis. Accordingly, the innate immune system recognizes highly conserved components associated with infections and damaged cells using a limited number of pattern-recognition receptors (PRRs), which are differentially expressed across cell types. LÄS MER

5. 14. Timing Matters : Wounding and entomopathogenic nematode infection kinetics

   Författare :Alexis Dziedziech; Ulrich Theopold; Angela Giangrande; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drosophila melanogaster; Heterorhabditis bacteriophora; Photorhabdus luminescens; entomopathogenic nematodes; worms; high-resolution microscopy; time-lapse; infection; kinetics; sepsis; septic wounding; injury; clotting; glutactin; transglutaminase; prophenoloxidase; cell death; pyroptosis; caspase; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : Over time, insects have developed complex strategies to defend themselves against presenting threats. However, in the evolutionary arms race of survival, pathogens have adapted to quickly overcome the immune response mounted by the host. LÄS MER

7. 15. Cellular remodeling in response to nutrient exhaustion : From membrane contact sites to autophagy

   Författare :Mahsa Ebrahimi; Sabrina Büttner; Cristina Mazzoni; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aging and longevity; yeast; phosphate restriction; interorganellar communication; autophagy; MVB pathway; NVJs; lipid droplets; nutritional regimes; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : Adaptation to fluctuating environments is critical for cellular fitness and survival. Cells need to sense changes in their surroundings and quickly adjust cellular homeostasis and metabolism accordingly. LÄS MER