Sökning: "calcineurin signaling"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden calcineurin signaling.

1. 1. Metal homeostasis as critical determinant for cellular fitness

   Författare :Jutta Diessl; Sabrina Büttner; Rajini Rao; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; metal homeostasis; manganese toxicity; coenzyme Q synthesis; mitochondrial respiration; calcineurin signaling; Pmr1; SPCA1; calcium; survival; caloric restriction; Parkinson’s disease models; proteotoxicity; Pep4; cathepsin D; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : Metals play a crucial role in cellular biology. Bulk and trace metals such as calcium and manganese regulate a plethora of cellular processes ranging from signaling and oxidative stress to proteostasis and energy metabolism. LÄS MER

3. 2. RUNX1/AML1 functions and mechanisms regulating granulocyte-macrophage colony-stimulating factor transcription

   Författare :Hebin Liu; Sven Påhlman; Umeå universitet; []
   Nyckelord :RUNX1 AML1; Granulocyte-macrophage colony-stimulating factor GM-CSF ; Calcineurin; CaMKII; Ets1; Transforming growth factor-b TGF-b ; Smad3; molekylärbiologi; Molecular Biology;

   Sammanfattning : Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multipotent cytokine involved in the production and function of hematopoietic cells, and GM-CSF plays in particular a major role in responses to infection and physiological and pathological inflammatory processes. GM-CSF is produced in many cell types, and increases in the intracellular Ca2+ concentration are, like in many other systems, of major importance in the intracellular signaling that determines GM-CSF expression after receptor stimulation of the cells. LÄS MER

4. 3. Akt signaling and coordinated changes in the distribution and expression of Akt-regulating phosphatases

   Författare :Aram Ghalali; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cancer is one of the major causes of death worldwide. The PI3K/Akt signaling pathway is up-regulated in a variety of human cancers. Akt is an important signaling molecule in cellular survival pathways. Activated Akt (pAkt) is able to induce protein synthesis pathways, and is therefore a key protein involved in growth and prevention of apoptosis. LÄS MER

5. 4. NFAT signaling in chronic and acute inflammation - A novel target for the treatment of diabetic vascular complications and acute pancreatitis?

   Författare :Anna Zetterqvist; Diabetiska komplikationer; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NFAT; vascular; diabetes; inflammation; atherosclerosis; diabetic retinopathy; acute pancreatitis; osteopontin; VCAM-1; A-285222;

   Sammanfattning : Diabetic patients suffer from macro- and microvascular complications causing increased morbidity and mortality. How hyperglycemia provokes vascular damage remains unclear, but glucose is believed to fuel a harmful low-grade chronic inflammation of the vessel wall. LÄS MER

7. 5. A molecular exploration of sensory responses in c. elegans

   Författare :Longjun Pu; Changchun Chen; Simon Tuck; Sara I Wilson; Zhiyong Shao; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; C. elegans; sensation; CRISPR Cas9; G protein-coupled receptors; neuropeptides; acute hypoxia; pathogen; chemosensation; hydrogen sulfide; HIF-1; iron;

   Sammanfattning : Sensation provides a pivotal ability, allowing animals to survive in complex environments. The cues sensed by animals are represented by external stimuli and internal signals. However, the mechanisms mediating sensations in molecular and cellular level are still not well-studied. In this thesis, by using free-living nematodes C. LÄS MER