Sökning: "caspase"

Visar resultat 1 - 5 av 251 avhandlingar innehållade ordet caspase.

  1. 1. Computational Prediction Models for Proteolytic Cleavage and Epitope Identification

    Detta är en avhandling från Department of Theoretical Physics, Lund University

    Författare :Liwen You; Högskolan i Halmstad.; Lunds universitet.; Lund University.; [2007]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TECHNOLOGY Bioengineering Bioinformatics; TEKNIKVETENSKAP Bioteknik Bioinformatik; Binding affinity; Caspase; Cleavage predition; Cleavage specifictiy; Epitope; False positive; Gaussian process; HCV; Hierarchial method; HIV; Immunology; MHC; OSRE; Protease-peptide interaction; Rule extraction; Sequence analysis; SVM; medical informatics; biomathematics biometrics; sequence analysis; rule extraction; protease-peptide interaction; immunology; hierarchical method; false positive; epitope; cleavage specificity; cleavage prediction; binding affinity; caspase; medicinsk informatik; biomatematik; Computer science; numerical analysis; systems; control; Datalogi; numerisk analys; system; kontroll;

    Sammanfattning : The biological functions of proteins depend on their physical interactions with other molecules, such as proteins and peptides. Therefore, modeling the protein-ligand interactions is important for understanding protein functions in different biological processes. LÄS MER

  2. 2. Caspase-dependent and caspase-independent neuronal injury in the developing brain

    Detta är en avhandling från Department of Theoretical Physics, Lund University

    Författare :Changlian Zhu; Göteborgs universitet.; Gothenburg University.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypoxia ischemia; neonatal; cell death; caspase; apoptosis-inducing factor; brain; apoptosis; autophagy; nitric oxide;

    Sammanfattning : Aims: To investigate the mechanisms of neuronal cell death after hypoxia-ischemia in the developing brain.Methods: Rats or mice were subjected to left common carotid artery ligation plus hypoxia. Animals were sacrificed at certain time points after hypoxia-ischemia. LÄS MER

  3. 3. Caspase activation in human neuroblastoma cells: mechanisms and spatiotemporal aspects

    Detta är en avhandling från Stockholm : Department of Neurochemistry

    Författare :Elena V. Ivanova; Stockholms universitet.; [2015]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; apoptosis; caspase; local caspase activation; neurodegeneration; tau-anchored FRET sensors; tAFS; cancer; neuroblastoma; TNF-related apoptosis inducing ligand; TRAIL; protein kinase C; PKC; X-linked inhibitor of apoptosis protein; XIAP; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Apoptosis is one of the modes of programmed cell death, in which several members of the caspase family of proteases play the central role. However, activation of apoptotic caspases does not necessarily lead to cell death. LÄS MER

  4. 4. Caspase-3 in lens epithelium

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Nooshin Talebizadeh; Uppsala universitet.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ultraviolet radiation; caspase-3; lens; cataract; apoptosis; Immunohistochemistry; spatial distribution; time evolution; modelling; automatic analysis; cell counting; image analysis.; Ophtalmology; Oftalmiatrik;

    Sammanfattning : Purpose: To model the time evolution of active caspase-3 protein expression in a healthy lens, and in a lens exposed to UVR-300 nm (UVR-B). To develop an automated method to classify the fluorescent signal of biomarkers in the lens epithelial cells.Methods: Six-week old Sprague-Dawley rats were used. LÄS MER

  5. 5. Amyotrophic Lateral Sclerosis – A Study in Transgenic Mice

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Hanna Wootz; Uppsala universitet.; [2006]
    Nyckelord :Neurosciences; ALS; Caspase; Caspase-12; Cathepsin; Cystatin; ER stress; Motor neuron; Neurodegeneration; Sod1; XIAP; Neurovetenskap;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an incidence of 1.5-2.7/100000 people/year. Today there is no cure for the disease and only symptomatic treatments are available. LÄS MER