Sökning: "pyroptosis"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet pyroptosis.

  1. 1. Inflammatory cell death of human macrophages induced by Aggregatibacter actinomycetemcomitans leukotoxin

    Författare :Peyman Kelk; Anders Johansson; Charels A Dinarello; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aggregatibacter actinomycetemcomitans; leukotoxin; IL-1β; caspase-1; inflammatory cell death; pyroptosis; ODONTOLOGY; ODONTOLOGI; odontologi; Odontology;

    Sammanfattning : Aggregatibacter (Actinobacillus) actinomycetemcomitans is a bacterium mainly associated with aggressive forms of periodontitis. Among its virulence factors, a leukotoxin is suggested to play an important role in the pathogenicity. LÄS MER

  2. 2. Characterization of the attenuated Francisella tularensis strain FSC043 : with special focus on the gene pdpC

    Författare :Marie Lindgren; Anders Sjöstedt; Marina Santic; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; intracellular bacteria; J774; apoptosis; pyroptosis; PdpC; FSC043; Clinical Bacteriology; klinisk bakteriologi; mikrobiologi; Microbiology;

    Sammanfattning : Francisella tularensis is a highly infective, intracellular bacterium. It is capable of infecting a wide range of mammals and causes the disease tularemia in humans. As a result of its high infectivity there have been a lot of efforts made to create a generally available vaccine against this pathogen. LÄS MER

  3. 3. Roles in innate immune receptors: Host : pathogen interactions and strengthening vaccines

    Författare :Sanna Nyström; Karolinska Institutet; Karolinska Institutet; []

    Sammanfattning : During the past decades our knowledge of innate immunology has increased drastically. This hasimproved our understanding about how innate immune cells can distinguish self from non-self, commensal bacteria from pathogens, and how it affects later adaptive immune responses. LÄS MER

  4. 4. Regulation of inflammasomes by host- and pathogen-derived factors

    Författare :Dora Hancz; Värd-patogeninteraktioner; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Innate Immunity; pattern recognition receptors; inflammasome; Streptococcus pyogenes;

    Sammanfattning : The term inflammasome was first coined in 2002 and describes an intracellular multiprotein complex mediating inflammation by inducing the release of pro-inflammatory cytokines (IL-1β and IL-18) and a lytic form of cell death called pyroptosis. Since then, an impressive amount of research has revealed many details about the mechanisms of inflammasome activation as well as the functional relevance of inflammasome activation in different contexts. LÄS MER

  5. 5. Inflammasomes : defense guardians in host-microbe defence

    Författare :Berolla Sahdo; Eva Särndahl; Bo Söderquist; Anna Norrby Teglund; Örebro universitet; []
    Nyckelord :Innate immunity; inflammasome; leukocytes; cytokines; Staphylococcus aureus; Propionibacterium acnes; inflammation; infection; gene variants; polymorphism.; Biomedicin; Biomedicine;

    Sammanfattning : The inflammasomes are emerging as key regulators of the innate immune response as they response to cellular infection, tissue damage and/or stress. Activated inflammasomes provide a signalling platform for caspase-1 activation which subsequently processes the maturation of interleukin (IL)-1β and IL-18, and in addition promotes cell death, named pyroptosis. LÄS MER