Sökning: "Anna-Lena Spetz"
Hittade 2 avhandlingar innehållade orden Anna-Lena Spetz.
1. The role of non-coding single-stranded oligonucleotides on Respiratory syncytial virus infection
Sammanfattning : Respiratory syncytial virus (RSV) is an enveloped RNA virus of the Pneumoviridae family. RSV is reported to infect host cells by receptor-mediated endocytosis, also called clathrin-dependent endocytosis. Many reports indicate that the virus utilizes the host receptor nucleolin for entry. LÄS MER
2. Harnessing the immunoregulatory capacity of single-stranded oligonucleotides to modulate innate immunity
Sammanfattning : As the first line of defense, the innate immune system is exceptionally efficacious against invading pathogens but must be tightly regulated to avoid immune-related pathogenesis. Accordingly, the innate immune system recognizes highly conserved components associated with infections and damaged cells using a limited number of pattern-recognition receptors (PRRs), which are differentially expressed across cell types. LÄS MER