Sökning: "Aging and longevity"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden Aging and longevity.

  1. 1. Links between Aging and Proteostasis Decline in Saccharomyces cerevisiae

    Författare :Veronica Andersson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; aging; aggregates; proteostasis; proteasome; disaggregation; peroxiredoxins; asymmetric inheritance; S. cerevisiae;

    Sammanfattning : Proteins are continuously synthesized and degraded to meet the demands of the cell. Hence, a proper balance between synthesis, folding, disaggregation and degradation is of essence to ensure cell survival. Disruption of any part of this proteostasis network may have severe consequences for cellular fitness and longevity. LÄS MER

  3. 2. On aging and the role of Ubp3 in heterochromatic gene silencing and protein quality control

    Författare :David Öling; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Aging; Protein damage; Segregation; Transcriptional silencing; rDNA; UBP3; SIR2; Protein aggregates;

    Sammanfattning : Aging is characterized by a build-up of damage in organisms ranging from protists to multi-cellular species. This damage adversely affects core components such as DNA and proteins which are necessary to sustain life. LÄS MER

  4. 3. Proteostasis and Aging in Saccharomyces cerevisiae - The role of a Peroxiredoxin

    Författare :Sarah Hanzén; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aging; Caloric restriction; Oxidative stress; Peroxiredoxins; Proteostasis; Protein aggregates; Ubiquitin-proteasome system;

    Sammanfattning : Aging is characterized by a progressive decline in physiological functions that limits biological processes, increases the risk of disease, and ultimately leads to death. At the cellular level, aging is associated with accumulation of damaged components, including proteins, indicating that protein homeostasis (or proteostasis) fails to maintain the integrity and functionality of the proteome as cells age. LÄS MER

  5. 4. Evaluation of Innovative Rehabilitation Technologies Utilising Polymer Composites for Aging Sewer Systems

    Författare :Parastou Kharazmi; Folke Björk; Tord af Klintberg; Tor Broström; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Civil and Architectural Engineering; Byggvetenskap;

    Sammanfattning : Water and wastewater sewer system maintenance is among the costliest aspects of infrastructure investment. The replacement of deteriorated lines is a difficult and expensive process that causes community disturbance and is generally not conducted fast enough to meet demand. LÄS MER

  7. 5. Fundamental studies of catalytic systems for diesel emission control

    Författare :Xavier Auvray; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NH3 SCR; NO oxidation; sulfur; hysteresis; kinetic modeling; SpaciMS; catalyst acidity; DOC; aging; Pt Al2O3;

    Sammanfattning : Due to global lean exhaust gas and new emission regulations, exhaust aftertreatment systems of diesel engines are more and more sophisticated and composed of a series of catalytic units. In the present work, two of these catalytic systems were studied with different approach. LÄS MER