Sökning: "mechanistic modelling"
Visar resultat 11 - 15 av 73 avhandlingar innehållade orden mechanistic modelling.
11. Pharmacometric Investigations of Prediction Precision and Advances of Models for Composite Scale Data
Sammanfattning : Clinical trials are needed to evaluate new treatments. In late-stage clinical trials, failures are mostly due to lack of efficacy. Fit-for-purpose analysis methods will likely increase the success rates and advance drug development by providing higher precision to support decisions such as go/no-go, dose selection, or sample size. LÄS MER
12. Unveiling Mechanistic Details of Macromolecular Interactions: Structural Design and Molecular Modelling of DNA-Protein Systems in Their Active State
Sammanfattning : Molecular structure is fundamental for understanding mechanisms of molecular interactions. This applies not least to understanding biological function: every biological cell, whether bacterial or human, is an immensely complex system of thousands of molecules that exist in constant motion and interaction with each other. LÄS MER
13. Hygroelastic behaviour of wood-fibre based materials on the composite, fibre and ultrastructural level
Sammanfattning : Wood fibres can be used as reinforcement in plastics for load carrying purposes. Some advantages compared with conventional man-made fibres are that wood fibres come from a renewable resource, have high specific stiffness and strength, are generally less hazardous to health, biodegradable, and can be manufactured at low cost and high volumes. LÄS MER
14. Pharmacodynamics of Enzyme Induction and its Consequences for Substrate Elimination
Sammanfattning : Enzyme induction is a process whereby a molecule enhances the expression of enzymes. If the affected enzymes are involved in the elimination of a drug, this may result in a drug interaction. Induction is therefore of major concern during drug development and in clinical practice. LÄS MER
15. Dynamics of forest soil chemistry
Sammanfattning : Acidification caused by emissions of Nitrogen and Sulphur and associated adverse effects on forest ecosystems has been an issue on the political agenda for decades. Temporal aspects of soil acidification and/or recovery can be investigated using the soil chemistry model SAFE, a dynamic version of the steady-state model PROFILE used in critical loads assessment on the national level, e. LÄS MER
