Sökning: "Rikard Sandström"

Hittade 4 avhandlingar innehållade orden Rikard Sandström.

  1. 1. Intestinal permeability and presystemic metabolism of R/S-verapamil and fluvastatin

    Författare :Rikard Sandström; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Sammanfattning : The rate and extent of absorption of drugs from the gastrointestinal tract into the systemiccirculation is defined as the bioavailability. The bioavailability is influenced by a numberof pharmaceutical, pharmacokinetic, biochemical and physiological factors. Two key-variables are the intestinal permeability and the presystemic metabolism. LÄS MER

  2. 2. Pharmacodynamics of Enzyme Induction and its Consequences for Substrate Elimination

    Författare :Mats O. Magnusson; Rikard Sandström; Mats Karlsson; Ulf Bredberg; Uppsala universitet; []
    Nyckelord :Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Enzyme induction; Time course; Turnover model; Mechanism-based; Modelling; NONMEM; Farmakokinetik Farmakoterapi;

    Sammanfattning : Enzyme induction is a process whereby a molecule enhances the expression of enzymes. If the affected enzymes are involved in the elimination of a drug, this may result in a drug interaction. Induction is therefore of major concern during drug development and in clinical practice. LÄS MER

  3. 3. Early Information Processing in the Vertebrate Olfactory System : A Computational Study

    Författare :Malin Sandström; Anders Lansner; Dominique Martinez; KTH; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; olfaction; olfactory system; olfactory bulb; synchronisation; CaMKII; mathematical modelling; Computer science; Datavetenskap;

    Sammanfattning : The olfactory system is believed to be the oldest sensory system. It developed to detect and analyse chemical information in the form of odours, and its organisation follows the same principles in almost all living animals - insects as well as mammals. LÄS MER

  4. 4. Computational Modelling of Early Olfactory Processing

    Författare :Malin Sandström; Anders Lansner; Jeanette Hällgren Kotaleski; Thomas Nowotny; KTH; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; olfaction; olfactory system; olfactory bulb; olfactory receptor neuron; synchronization; CaMKII; mathematical modelling; lukt; luktsystemet; luktbulben; synkronisering; CaMKII; matematisk modellering; Computer science; Datavetenskap;

    Sammanfattning : Chemical sensing is believed to be the oldest sensory ability. The chemical senses, olfaction and gustation, developed to detect and analyze information in the form of air- or waterborne chemicals, to find food and mates, and to avoid danger. LÄS MER