Sökning: "Enzyme induction"
Visar resultat 1 - 5 av 175 avhandlingar innehållade orden Enzyme induction.
1. Pharmacodynamics of Enzyme Induction and its Consequences for Substrate Elimination
Sammanfattning : Enzyme induction is a process whereby a molecule enhances the expression of enzymes. If the affected enzymes are involved in the elimination of a drug, this may result in a drug interaction. Induction is therefore of major concern during drug development and in clinical practice. LÄS MER
2. Cytochrome P450 enzymes affected by artemisinin antimalarials-pharmacokinetic and pharmacogenetic aspects
Sammanfattning : With more than 500 million cases and at least 1 million deaths each year, malaria is a major global health problem. The main problem with malaria control is the emerging drug resistance among parasites causing the infection. Consequently, there is an urgent need for new drugs. LÄS MER
3. Regulation of morphogen signalling during neural patterning in the Xenopus embryo
Sammanfattning : Morphogens such as Hedghog, Wnt, FGF, and retinoic acid are important signals whose concentrations need to be tightly regulated in the vertebrate embryo to ensure body axis development and formation of the central nervous system. We first show that the intracellular cytoplasmic protein XSufu acts as a dual regulator of Hedgehog (Hh) and Wnt signals during neural induction and patterning in the Xenopus embryo. LÄS MER
4. The development of a new combined adjuvant vector for mucosal immunization CTA1-DD/ISCOM
Sammanfattning : The CTA1-DD/ISCOMs vector is a rationally designed mucosal adjuvant that was developed to host the distinctive properties of either adjuvant alone or in a combination that hosted additive enhancing effects on mucosal immune responses. Here I demonstrate that CTA1-DD can be incorporated into the ISCOM with greatly augmented immunogenicity of both incorporated and admixed antigen. LÄS MER
5. Induction of human cytochrome P450 enzymes : predictive in vitro models and rifampicin induction in vivo
Sammanfattning : The cytochrome P450 (P450) enzymes comprise the most important enzyme system with regard to phase I metabolism of drugs. Induction of P450s can result in decreased plasma concentrations of the drug itself or a coadminstered drug, followed by lack of effect. LÄS MER