Sökning: "mechanistic modelling"

Visar resultat 21 - 25 av 73 avhandlingar innehållade orden mechanistic modelling.

  1. 21. Mechanistic modelling - a BOLD response to the fMRI information loss problem

    Författare :Karin Lundengård; Maria Engström; Gunnar Cedersund; Fredrik Elinder; Susanna Walter; Kâmil Uludağ; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Functional Magnetic Resonance Imaging (fMRI) is a common technique for imaging brain activity in humans. However, the fMRI signal stems from local changes in oxygen level rather than from neuronal excitation. LÄS MER

  3. 22. Modelling nutrient transport from forest ecosystems to surface waters : The model ForSAFE-2D

    Författare :Giuliana Zanchi; Institutionen för naturgeografi och ekosystemvetenskap; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; forest; dynamic modelling; hydrology; biogeochemistry; ecosystem service;

    Sammanfattning : Forests provide multiple products and services which are all are linked to water resources. Trees need water to grow and, at the same time, they change the quality and the quantity of runoff by modifying water and nutrient cycling. LÄS MER

  4. 23. Quantifying effects of antimicrobial drug combinations by modelling and simulation

    Författare :Chenyan Zhao; Lena Friberg; Elisabet I. Nielsen; Shampa Das; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics and pharmacodynamics; modelling and simulation; antibiotic combination; model-based translation; antibiotic resistance; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Antibiotic resistance is becoming an accelerating issue, both in the treatment of nosocomial infections and for public health in general. There is a pressing need for innovative methods to understand how available antibiotics could be combined to overcome and limit the emergence of resistance. LÄS MER

  5. 24. Characterisation of an in vitro dissolution method for assessment of novel pulmonary drug delivery systems : With a focus on controlled release systems

    Författare :Irès van der Zwaan; Göran Frenning; Per Hansson; Rebecca Fransson; Alessandra Rossi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pulmonary drug delivery; in vitro dissolution; mechanistic model; controlled release; physiologically based biopharmaceutics modelling;

    Sammanfattning : Pulmonary drug delivery has been used for decades to treat local diseases like asthma. When using the pulmonary route to deliver drugs, several important lung features are being used, such as a large surface area available for absorption, high organ vascularization, and a thin blood-alveolar barrier. LÄS MER

  7. 25. Quantum Chemical Modelling of Biomimetic Phosphoesterase Complexes

    Författare :Henrik Daver; Fahmi Himo; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Phosphoesterases are a class of enzymes that catalyze hydrolysis of phosphoester bonds. They facilitate the modification of nucleic acid sequences, as well as the breakdown of rest products of warfare agents and insecticides. In this thesis, three biomimetic complexes that perform the same tasks are studied using density functional theory. LÄS MER