Sökning: "masspektrometri"

Visar resultat 1 - 5 av 67 avhandlingar innehållade ordet masspektrometri.

  1. 1. An Organic Chemistry Odyssey : Imaging Mass Spectrometry in Neurotherapeutics, Asymmetric Methodology Development and Natural Product Synthesis

    Författare :Marvin Villacrez; Kemisk biologi med inriktning mot läkemedelsutveckling; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Masspektrometri; totalsyntes; avbildande massspektrometri; MALDI avbildande massspektrometri; asymmetrisk syntes; farmakokinetik; dynamisk kinetisk resolution; Aasymetrisk överföringshydrogenering; klozapin; Läkemedelsmetabolism; läkemedelsdistribution; aminoalkoholer; Aspidophylline A; mass spectromery; Imaging mass spectrometry; Total synthesis; Dynamic kinetic resolution; asymmetric transfer hydrogenation; Aspidophylline A; Drug distribution; Drug metabolism; Drug Metabolism and Mass Spectrometry Imaging; MALDI mass spectrometry imaging; clozapine; amino alcohols; pharmacokinetics;

    Sammanfattning : The development of imaging technologies and brain models is crucial for advancements in neurotherapeutic drug discovery and development. They assume a critical role in evaluating essential parameters such as drug blood-brain barrier (BBB) permeation, distribution, and metabolism, all of which are vital for the development of safe and effective medications. LÄS MER

  3. 2. The Impact of Hydrocarbon and Carbon Oxide Impuritiesin the Hydrogen Feed of a PEM Fuel Cell

    Författare :Katrin Kortsdottir; Rakel Wreland Lindström; Göran Lindbergh; Tanja Kallio; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Fuel Cell; Hydrogen Impurities; Carbon Monoxide; Carbon Dioxide; Ethene; Propene; Methane; Propane; Toluene; Electrochemically Active Surface Area; Cyclic Voltammetry; Mass Spectrometry; bränslecell; vätgasföroreningar; kolmonoxid; koldioxid; eten; propen; metan; propan; toluen; elektrokemisk aktiv yta; cyklisk voltammetri; masspektrometri; Chemical Engineering; Kemiteknik;

    Sammanfattning : The proton exchange membrane fuel cell generates electricity from hydrogen and oxygen (from air) through electrocatalytic reactions in an electrochemical cell. The Pt/C catalyst, commonly used in PEM fuel cells, is very sensitive to impurities that can interact with the active catalyst sites and limit fuel cell performance. LÄS MER

  4. 3. Identification of tissue biomarkers of prognostic significance in pancreatic cancer

    Författare :Dingyuan Hu; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic cancer; proteomics; mass spectrometry; Biomarkers; prognosis; CLCA1; pankreascancer; proteomik; masspektrometri; biomarkörer; prognos; CLCA1;

    Sammanfattning : Background: Pancreatic cancer is the third leading cause of cancer-related mortality. Lack of early detection strategies and therapeutic resistance are main contributors to the poor prognosis. Unfortunately, there are no tissue biomarkers available for the prognosis of pancreatic cancer in routine clinical use. LÄS MER

  5. 4. Lipoproteomics : A New Approach to the Identification and Characterization of Proteins in LDL and HDL

    Författare :Helen Karlsson; Mats Lindahl; Christer Tagesson; Pia Davidsson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LDL; HDL; Proteomik; Atheroskleros; Masspektrometri; 2-DE; Molecular medicine; Molekylär medicin;

    Sammanfattning : A proteomic approach was applied to examine the protein composition of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) in humans. LDL and HDL were isolated by density gradient ultracentrifugation, and proteins were separated with twodimensional gel electrophoresis (2-DE) and identified with peptide mass fingerprinting, using matrix-assisted laser desorption/ionization-time of flight mass spectrometry, and with amino acid sequencing using electrospray ionization tandem mass spectrometry. LÄS MER

  7. 5. Proteomic Analysis of Urinary Bladder Cancer : Aiming for Novel Biomarkers

    Författare :Mårten Lindén; Per-Uno Malmström; Ulrika Segersten; Sara Bergström Lind; Lars Egevad; Uppsala universitet; []
    Nyckelord :urine; APOE; FGB; GAL1; LRG1; POLR1E; SERPINA1; STMN1; TOP2A; biomarker; diagnostic biomarker; prognostic biomarker; predictive biomarker; mass spectrometry; western blot; dot blot; immunohistochemistry; IHC; tissue microarray; TMA; urothelium; antibody; antibody-based; urinblåsecancer; biomarkör; diagnos; prognos; urin; proteomik; masspektrometri; immunohistokemi; antikroppar; Molecular Biology; Molekylärbiologi; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Urinary bladder cancer is a heterogeneous disease appearing in different forms, e.g. non-muscle invasive and muscle invasive. For all variants, the expression of proteins is interesting to analyze for diagnostic, predictive, prognostic and drug targeting purposes, since it reflects the altered gene expression causing the cancer. LÄS MER