Visar resultat 1 - 5 av 150 avhandlingar innehållade ordet APOE.
Sammanfattning : Olfactory function is impaired in aging and dementia. The general aim of this thesis was to identify variables that predict olfactory function and dysfunction (assessed with an odor identification test) in middle-aged and elderly adults. LÄS MER
Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia and cerebrospinal fluid (CSF) biomarkers reflecting the core pathology of AD are now widely used for diagnosis making, in particular β-amyloid[1-42] (Aβ42) reflecting amyloid plaque pathology, phosphorylated tau (P-tau) reflecting neurofibrillary tangle pathology and total tau (T-tau) reflecting general neurodegeneration. In addition, blood-based biomarkers for AD are in the pipeline with recent studies showing promising diagnostic potential. LÄS MER
3. Polyphenols in Swedish berries and pulses : Characterization and in vivo effects of fractions from lingonberries and brown beans in an Apoe-/- mouse model
Sammanfattning : Consumption of berries and pulses can protect against atherosclerosis and other metabolic diseases, by modulating plasma lipid profile, gut microbiota, and microbiota-dependent metabolites. These nutritional benefits are often attributed to high content of polyphenols (flavonoids and phenolic acids) and dietary fiber. LÄS MER
4. Cognitive change in aging: A life span perspective of gender and individual differences in APOE genotype
Sammanfattning : Degree of licentiate in Psychology Abstract Praetorius, M. (2011). Cognitive change in aging: A life span p erspective of gender and individual differences in APOE genotype. LÄS MER
Sammanfattning : In the field of imaging genetics, brain function and structure are used as intermediate phenotypes between genes and cognition/diseases to validate and extend findings from behavioral genetics. In this thesis, three of the strongest candidate genes for episodic memory, KIBRA, BDNF, and APOE, were examined in relation to memory performance and hippocampal/parahippocampal fMRI blood-oxygen level-dependent (BOLD) signal. LÄS MER