Sökning: "masspektrometri"

Visar resultat 6 - 10 av 66 avhandlingar innehållade ordet masspektrometri.

  1. 6. Analytical Approaches to Neurodegenerative Disease Protein Aggregation

    Författare :Henning Wiberg; Åsa Emmer; Torbjörn Gräslund; Leopold Ilag; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; neurodegenerative diseases; protein misfolding; protein aggregation; gel electrophoresis; isoelectric focusing; immunodetection; ELISA; immunoprecipitation; mass spectrometry; nanoelectrospray; liquid chromatography; neurodegenerativa sjukdomar; felveckade proteiner; proteinaggregering; geleektrofores; isoelektrisk fokusering; immundetektion; ELISA; immunoprecipitering; masspektrometri; nanoelektrospray; vätskekromatografi; Analytical chemistry; Analytisk kemi;

    Sammanfattning : .... LÄS MER

  3. 7. High Rate Electron Capture Dissociation Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

    Författare :Youri Tsybin; Per Håkansson; Ron M.A. Heeren; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physics; mass spectrometry; Fourier transform ion cyclotron resonance; peptides and proteins; ion-electron interaction; electron capture dissociation; infrared multiphoton dissociation; liquid chromatography; capillary electrophoresis; Fysik; Physics; Fysik;

    Sammanfattning : Advances in science and technology during the past decade have greatly enhanced the level of the structural investigation of macromolecules – peptides and proteins. Biological mass spectrometry has become one of the most precise and sensitive techniques in peptide and protein analysis. LÄS MER

  4. 8. Development of Sheathless Electrospray Mass Spectrometry and Investigations of Associated Electrochemical Processes – A Fairy Tale

    Författare :Stefan Nilsson; Karin Markides; Leif Nyholm; Jonas Bergquist; Per Andrén; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; electrospray; sheathless; mass spectrometry; capillary electrophoresis; electrochemistry; chromatography; interface; fairy dust; gold; Analytisk kemi; Analytical chemistry; Analytisk kemi;

    Sammanfattning : In microscale separations, such as capillary electrophoresis and -liquid chromatography, the liquid flow rates are in the order of nanoliters per second. If such flow rates are to be interfaced with a mass spectrometer (MS) using electrospray (ES) ionization, without loss of separation efficiency, each fraction of the analyte zone must remain undisturbed by the high voltage contact necessary for ES. LÄS MER

  5. 9. Development of Techniques and Methods for the Quantitative Analysis of Endogenous Substances by Microcolumn Liquid Chromatography Coupled to Mass Spectrometry

    Författare :Ardeshir Amirkhani; Jonas Bergquist; Karin E. Markides; Fritz Erni; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; Analytisk kemi; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Liquid chromatography-mass spectrometry (LC-MS) is a powerful technique for the analysis of endogenous compounds. The introduction of electrospray ionization (ESI) as an interface between LC and MS has contributed strongly to a trend towards miniaturization of LC, due to the possibility to perform ESI at low flow rates. LÄS MER

  7. 10. Improved techniques for CE-MALDI-MS off-line coupling and MALDI-MS analysis of primarily hydrophobic proteins and peptides

    Författare :Johan Jacksén; Åsa Emmer; Anna Karin/Minna Borg Karlsson/Hakkarainen; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Capillary electrophoresis; Hydrophobic peptides; Matrix-Assisted Laser Desorption Ionization Mass Spectrometry; Prestructured target; Off-line interface; Silicon microcanal; Matrix; Protein cleavage digestion.; Kapillärelektrofores; Hydrofoba peptider; Matris-assisterad laserdesorptions-joniserings-masspektrometri; Strukturbelagd provplatta; Off-line interface; Mikrokanal i kisel; Matris; Proteinklyvning -spjälkning.; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Due to the hydrophobic nature of integral membrane proteins (IMP) they give rise to several difficulties concerning handling and analysis, which is not the case for the most water soluble proteins. New analysis methods are needed, where the insolubility problems of the hydrophobic proteins due to aggregation and adhesion are tackled. LÄS MER