Sökning: "diagnostic biomarker"

Visar resultat 1 - 5 av 100 avhandlingar innehållade orden diagnostic biomarker.

  1. 1. Proteomic Analysis of Urinary Bladder Cancer Aiming for Novel Biomarkers

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Mårten Lindén; Uppsala universitet.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; urine; APOE; FGB; GAL1; LRG1; POLR1E; SERPINA1; STMN1; TOP2A; biomarker; diagnostic biomarker; prognostic biomarker; predictive biomarker; mass spectrometry; western blot; dot blot; immunohistochemistry; IHC; tissue microarray; TMA; urothelium; antibody; antibody-based; urinblåsecancer; biomarkör; diagnos; prognos; urin; proteomik; masspektrometri; immunohistokemi; antikroppar; Molecular Biology; Molekylärbiologi; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Urinary bladder cancer is a heterogeneous disease appearing in different forms, e.g. non-muscle invasive and muscle invasive. For all variants, the expression of proteins is interesting to analyze for diagnostic, predictive, prognostic and drug targeting purposes, since it reflects the altered gene expression causing the cancer. LÄS MER

  2. 2. Measuring distal airspace dimensions with nanoparticles. Initial development of a diagnostic method

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :H Laura Aaltonen; Lund University.; Lunds universitet.; [2019]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nanoparticles; COPD; AiDA; biomarker;

    Sammanfattning : Chronic obstructive pulmonary disease (COPD) consists of emphysema and bronchial disease. The pulmonary function tests currently used to diagnose COPD have poor sensitivity for early disease. This may delay diagnosis and lead to a poorer prognosis compared to establishing the diagnosis at an earlier stage. LÄS MER

  3. 3. Clinical studies of RNA as a prognostic and diagnostic marker for disease

    Detta är en avhandling från Örebro : Örebro University

    Författare :Helena Isaksson; Örebro universitet.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gene expression; ovarian cancer; hypercalprotectinaemia; hyperzincaemia; ischemia; biomarker;

    Sammanfattning : Technologies for RNA detection are evolving rapidly and gives an op-portunity for discovery of new markers for early detection of complex diseases. Today in clinical work we rely on signs and symptoms in com-bination with the measurement of protein levels for diagnosis. LÄS MER

  4. 4. Tethered Lipid Vesicles as Nanoscale Sensor Elements

    Detta är en avhandling från Örebro : Örebro University

    Författare :Seyed Tabaei; [2012]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; aquaglyceroporin; lipid vesicles; total internal reflection fluorescence TIRF microscopy; cell membrane; aquaporin; pore formation; surface plasmon resonance SPR ; phospholipase A2; antiviral peptide; lipid bilayer; biosensing; microfluidics;

    Sammanfattning : The primary aim of this thesis work has been to explore and advance the potential of surface tethered lipid vesicles as a platform for studying in particular the following three biomembrane-related processes: trans-membrane transport, membrane-peptide interactions and the activity of membrane active enzymes. First, a method based on surface plasmon resonance (SPR) spectroscopy was developed for studying passive diffusion processes as well as the membrane-protein mediated transport of small non electrolyte molecules across lipid bilayers. LÄS MER

  5. 5. CSF biomarkers reflecting beta-amyloid and axonal pathology in Alzheimer's disease and related conditions

    Detta är en avhandling från Örebro : Örebro University

    Författare :Niklas Mattsson; Göteborgs universitet.; Gothenburg University.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; biomarker; cerebrospinal fluid; beta-amyloid; axonal; Niemann-Pick type C; neuroborreliosis;

    Sammanfattning : Cerebrospinal fluid (CSF) biomarkers may be used to identify and monitor pathological processes in the central nervous system. CSF biomarkers in Alzheimer’s disease (AD) include β-amyloid 42 (Aβ42), total-tau (T-tau) and phosphorylated-tau (P-tau), reflecting brain amyloid, axonal and tangle pathology, respectively. LÄS MER