Sökning: "proteomik"

Visar resultat 1 - 5 av 70 avhandlingar innehållade ordet proteomik.

  1. 1. Identification of tissue biomarkers of prognostic significance in pancreatic cancer

    Författare :Dingyuan Hu; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic cancer; proteomics; mass spectrometry; Biomarkers; prognosis; CLCA1; pankreascancer; proteomik; masspektrometri; biomarkörer; prognos; CLCA1;

    Sammanfattning : Background: Pancreatic cancer is the third leading cause of cancer-related mortality. Lack of early detection strategies and therapeutic resistance are main contributors to the poor prognosis. Unfortunately, there are no tissue biomarkers available for the prognosis of pancreatic cancer in routine clinical use. LÄS MER

  3. 2. Lipoproteomics : A New Approach to the Identification and Characterization of Proteins in LDL and HDL

    Författare :Helen Karlsson; Mats Lindahl; Christer Tagesson; Pia Davidsson; Linköpings universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LDL; HDL; Proteomik; Atheroskleros; Masspektrometri; 2-DE; Molecular medicine; Molekylär medicin;

    Sammanfattning : A proteomic approach was applied to examine the protein composition of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) in humans. LDL and HDL were isolated by density gradient ultracentrifugation, and proteins were separated with twodimensional gel electrophoresis (2-DE) and identified with peptide mass fingerprinting, using matrix-assisted laser desorption/ionization-time of flight mass spectrometry, and with amino acid sequencing using electrospray ionization tandem mass spectrometry. LÄS MER

  4. 3. Proteomic Analysis of Urinary Bladder Cancer : Aiming for Novel Biomarkers

    Författare :Mårten Lindén; Per-Uno Malmström; Ulrika Segersten; Sara Bergström Lind; Lars Egevad; Uppsala universitet; []
    Nyckelord :urine; APOE; FGB; GAL1; LRG1; POLR1E; SERPINA1; STMN1; TOP2A; biomarker; diagnostic biomarker; prognostic biomarker; predictive biomarker; mass spectrometry; western blot; dot blot; immunohistochemistry; IHC; tissue microarray; TMA; urothelium; antibody; antibody-based; urinblåsecancer; biomarkör; diagnos; prognos; urin; proteomik; masspektrometri; immunohistokemi; antikroppar; Molecular Biology; Molekylärbiologi; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Urinary bladder cancer is a heterogeneous disease appearing in different forms, e.g. non-muscle invasive and muscle invasive. For all variants, the expression of proteins is interesting to analyze for diagnostic, predictive, prognostic and drug targeting purposes, since it reflects the altered gene expression causing the cancer. LÄS MER

  5. 4. Multivariate analyses of proteomic and metabolomic patterns in brain tumors

    Författare :Carl Wibom; A Tommy Bergenheim; Henrik Antti; Mikael Johansson; Janne Lehtiö; Umeå universitet; []
    Nyckelord :glioblastoma; meningioma; proteomics; metabolomics; multivariate analyses; onkologi; Oncology;

    Sammanfattning : Glioblastoma multiforme (GBM) is the most common primary brain tumor. Given the current standard of care, the prognosis for patients diagnosed with this disease is still poor. There consequently exists a need to improve current treatments, as well as to develop new ones. LÄS MER

  7. 5. New Proteomics Methods and Fundamental Aspects of Peptide Fragmentation

    Författare :Mikhail Savitski; Roman Zubarev; Per Andren; David Fenyö; Uppsala universitet; []
    Nyckelord :Bioinformatics; Proteomics; Peptide fragmentation; Bioinformatik;

    Sammanfattning : The combination of collision-activated dissociation, (CAD) and electron capture dissociation, (ECD) yielded a 125% increase in protein identification. The S-score was developed for measuring the information content in MS/MS spectra. This measure made it possible to single out good quality spectra that were not identified by a search engine. LÄS MER