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Visar resultat 6 - 10 av 144 avhandlingar som matchar ovanstående sökkriterier.

1. 6. Expression of stimulatory and inhibitory molecules in interactions between natural killer cells neurons

   Författare :Eva Backström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Nervous system; brain; neuron; NK cells; dorsal root ganglia; hippocampus; NKG2D; RAE 1; MULT1; nerve lesion; influenza virus; MCMV.;

   Sammanfattning : Natural killer (NK) cells are important effector cells of the innate and the early induced immune defense. In the nervous system they appear early during inflammation and have been ascribed a role in clearance of certain viral infections from the brain. NK cells are regulated by multiple signals transmitted via inhibitory and stimulatory receptors. LÄS MER

3. 7. Characterisation of inputs and outputs of striatal medium spiny neurons in health and disease

   Författare :Marko Filipović; Jeanette Hellgren Kotaleski; Arvind Kumar; Gilad Silberberg; Ad Aertsen; Andrew Sharott; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; basal ganglia; striatum; medium spiny neurons; subthalamic nucleus; globus pallidus; Parkinson s disease; in vivo; oscillations; spectral analysis; response variability; networks; simulations; modelling; Numerical Analysis; Numerisk analys; Computer Science; Datalogi; Biological and Biomedical Physics; Biologisk och biomedicinsk fysik;

   Sammanfattning : Striatal medium spiny neurons (MSNs) play a crucial role in various motor and cognitive functions. They are separated into those belonging to the direct pathway (dMSNs) and the indirect pathway (iMSNs) of the basal ganglia, depending on whether they express D1 or D2 type dopamine receptors, respectively. LÄS MER

4. 8. Towards cell replacement therapy in Parkinson’s disease. Proteoglycans and Nogo-A as modulators of axonal growth in midbrain dopaminergic neurons

   Författare :Zuzanna Kurowska; Neural plasticitet och reparation; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LUHMES cells; substantia nigra pars compacta; microarray; heparan sulphate 3-O-sulfotransferase; neurocan; midbrain dopaminergic neurons; grafting; embryonic stem cells; proteoglycans; glycosaminoglycans; Nogo-A; cell replacement therapy; Parkinson’s disease;

   Sammanfattning : Parkinson’s disease (PD) is currently the second most common neurodegenerative disorder (after Alzheimer’s disease). PD is diagnosed on its motor symptoms, which include akinesia, bradykinesia, rigidity, postural imbalance and resting tremor. It is well established that the motor symptoms develop due to lack of dopamine in the striatum. LÄS MER

5. 9. Multiple neurotransmitter inputs modulate circadian clock neurons in Drosophila

   Författare :Yasutaka Hamasaka; Dick Nässel; François Rouyer; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; circadian; Drosophila; neurotransmitter; G-protein coupled receptor; Neurobiology; Neurobiologi;

   Sammanfattning : Most animals have endogenous circadian clocks, which drive daily rhythms in behavior and physiology to adapt to daily cycles of the environment. Several sets of neurons have been identified as circadian pacemakers (clocks) in the brain of Drosophila melanogaster, but the neuronal circuits and neurotransmitters signalling circadian information are poorly known. LÄS MER

7. 10. Functional Imaging of Spinal Locomotor Networks

   Författare :Chetan Nagaraja; Klas Kullander; Gilad Silberberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Central pattern generators; two-photon microscopy; locomotor rhythm; multiple rhythmicities; inhibitory neurotransmission; Neuroscience; Neurovetenskap;

   Sammanfattning : Movement is necessary for the survival of most animals. The spinal cord contains neuronal networks that are capable of motor coordination and of producing different movements. In particular, a very reduced neuronal network in the spinal cord can produce simple rhythmic outputs even in the absence of descending or sensory inputs. LÄS MER