Sökning: "subthalamic nucleus"

Visar resultat 1 - 5 av 23 avhandlingar innehållade orden subthalamic nucleus.

  1. 1. The subthalamic nucleus in motor and affective functions : An optogenetic in vivo-investigation

    Författare :Adriane Guillaumin; Åsa Wallén-Mackenzie; Konstantinos Meletis; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Subthalamic nucleus; optogenetics; basal ganglia; locomotion; Parkinson s disease; aversion; Neuroscience; Neurovetenskap;

    Sammanfattning : The basal ganglia form a group of subcortical interconnected nuclei involved in motor, limbic and cognitive functions. According to the classical model of the basal ganglia, two main pathways exert opposing control over movement, one facilitating movement and the other suppressing movement. LÄS MER

  3. 2. Across Borders : A Histological and Physiological Study of the Subthalamic Nucleus in Reward and Movement

    Författare :Nadine Schweizer; Åsa Wallén-Mackenzie; Dai Stephens; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; subthalamic nucleus; STN; basal ganglia; locomotion; hyperlocomotion; rearing; ventral tegmental area; VTA; dopamine; glutamate; vesicular glutamate transporter 2; Vglut2; Parkinson s disease; deep brain stimulation; subpopulation; conditional knock-out; optogenetic; co-expression; in situ hybridization; self-administration; reward behavior; mouse genetics;

    Sammanfattning : The basal ganglia are the key circuitry controlling movement and reward behavior. Both locomotion and reward-related behavior are also modified by dopaminergic input from the substantia nigra and the ventral tegmental area (VTA). LÄS MER

  4. 3. Motion and Emotion : Functional In Vivo Analyses of the Mouse Basal Ganglia

    Författare :Emma Arvidsson; Åsa Wallén-Mackenzie; Cecilia Flores; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dopamine; Basal Ganglia; Reward System; In Vivo Chronoamperometry; Optogenetics; Deep Brain Stimulation; Parkinson’s Disease; Addiction; Glutamate; Vesicular Glutamate Transporter; VGLUT2; Sex; Age; Subthalamic Nucleus; Striatum; Nucleus Accumbens; Ventral Tegmental Area;

    Sammanfattning : A major challenge in the field of neuroscience is to link behavior with specific neuronal circuitries and cellular events. One way of facing this challenge is to identify unique cellular markers and thus have the ability to, through various mouse genetics tools, mimic, manipulate and control various aspects of neuronal activity to decipher their correlation to behavior. LÄS MER

  5. 4. Balance performance in people with Parkinson’s disease. Effects of subthalamic Deep Brain Stimulation

    Författare :Maria H Nilsson; Aktivt och hälsosamt åldrande; []
    Nyckelord :Parkinson s disease; Deep Brain Stimulation; subthalamic nucleus; balance; falls.; fear of falling;

    Sammanfattning : The overall aims of this work were to investigate if Deep Brain Stimulation in the subthalamic nuclei (STN) affected balance, fear of falling and falls in people with Parkinson's disease. The effect of STN stimulation alone was investigated in Papers I, II and III. LÄS MER

  7. 5. United in Diversity : A Physiological and Molecular Characterization of Subpopulations in the Basal Ganglia Circuitry

    Författare :Thomas Viereckel; Åsa Wallén-Mackenzie; Åsa Konradsson-Geuken; Erika Comasco; Per Svenningsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Glutamate; Optogenetics; Amperometry; Histology; Midbrain; Subthalamic Nucleus; Parkinson s disease; Ventral Tegmental Area; Substantia Nigra; Co-release;

    Sammanfattning : The Basal Ganglia consist of a number of different nuclei that form a diverse circuitry of GABAergic, dopaminergic and glutamatergic neurons. This complex network is further organized in subcircuits that govern limbic and motor functions in humans and other vertebrates. LÄS MER