Sökning: "Jeanette Hellgren Kotaleski"
Visar resultat 1 - 5 av 14 avhandlingar innehållade orden Jeanette Hellgren Kotaleski.
1. Modeling of bursting mechanisms and coordination in a spinal central pattern generator
Sammanfattning : Mechanisms underlying lotal bursting as well as coordinationbetween different levels of a spinal CPG generating locomotionhave been investigated using computer simulations. A"primitive" jawless vertebrate, the lamprey, is used a.s aprototype model. LÄS MER
2. Untangling Cortico-Striatal Circuitry and its Role in Health and Disease - A computational investigation
Sammanfattning : The basal ganglia (BG) play a critical role in a variety of regular motor and cognitive functions. Many brain diseases, such as Parkinson’s diseases, Huntington’s disease and dyskinesia, are directly related to malfunctions of the BG nuclei. LÄS MER
3. Method development for co-simulation of electrical-chemical systems in Neuroscience
Sammanfattning : Multiscale modeling and simulation is a powerful approach for studying such phenomena in nature as learning and memory. In computational neuroscience, historically, methods and tools for neuronal modeling and simulations have been developed for studies focused on a single level of the neuronal organization. LÄS MER
4. Computational Modelling and Topological Analysis of the striatal microcircuitry in health and Parkinson's disease
Sammanfattning : The basal ganglia are evolutionary conserved nuclei located at the base of the forebrain. They are a central hub in the control of motion and their dysfunctions lead to a variety of movement related disorders, including Parkinson's disease (PD).The largest nucleus and main input stage of the basal ganglia is the striatum. LÄS MER
5. Characterisation of inputs and outputs of striatal medium spiny neurons in health and disease
Sammanfattning : Striatal medium spiny neurons (MSNs) play a crucial role in various motor and cognitive functions. They are separated into those belonging to the direct pathway (dMSNs) and the indirect pathway (iMSNs) of the basal ganglia, depending on whether they express D1 or D2 type dopamine receptors, respectively. LÄS MER