Sökning: "histamine H2-receptors"

Hittade 5 avhandlingar innehållade orden histamine H2-receptors.

  1. 1. Treatment of malignant tumors with histamine. Clinical and experimental studies

    Författare :Magnus Rizell; Göteborgs universitet; []
    Nyckelord :histamine; histamine H2-receptors; microdialysis; pharmacokinetics; ; neoplasm; sarcoma; melanoma; immunotherapy;

    Sammanfattning : For metastatic melanoma there is no treatment to prolong life. Histamine has in experimental tumors shown tumor inhibiting effects. In vitro, histamine inhibit phagocyte-derived radical oxygen species to protect natural killer and cytotoxic T-lymphocytes. LÄS MER

  3. 2. Histamine receptors and neuropeptides in the cranial circulation

    Författare :Anders Ottosson; Rättsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; neuropsychology; Neurology; Human - arteries - CGRP - SP - mast cells; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : The sensory neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) are present in human cerebral, meningeal and temporal arteries, as are peptides associated with the sympathetic (neuropeptide Y, NPY) and parasympathetic (vasoactive intestinal peptide, VIP) nervous system. NPY is a vasoconstrictor in cerebral and meningeal arteries and potentiates noradrenaline (NA) as a vasoconstrictor in temporal arteries. LÄS MER

  4. 3. Mediator synergism in mast celldependent inflammation : role of histamine for leukocyte recruitment

    Författare :Henrik Thorlacius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Chemoattractants; dexamethasone; histamine; inflammation; intravital microscopy; mast cells; leukocyte adhesion; leukocyte rolling; microcirculation; mast cells; nitric oxide; leukotrienes; P-selectin.;

    Sammanfattning : The aim of the present thesis was to study functional interactions between histamine and chemotactic mediators, and the role of histamine for leukocyte recruitment in mast cell-dependent inflammation. Leukocyte rolling, adhesion and emigration. LÄS MER

  5. 4. Modelling depression in animals and the potential antidepressant effect of histaminergic modulation

    Författare :Salvatore Magara; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Depression is at the top position for "years lived with disability" (Smith, 2014). Its aetiology is unknown, but the pathogenesis implicates changes in glutamatergic neuronal plasticity. Glutamatergic plasticity likely mediates the effects of antidepressants acting through monoamines. LÄS MER

  7. 5. Mechanisms of leukemia-induced immunosuppression

    Författare :Johan Aurelius; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia; Immunosuppression; Immunotherapy; Reactive oxygen species; PARP-1; NK cells; T cells;

    Sammanfattning : This thesis aimed to define the role of reactive oxygen species (ROS), produced by the NADPH oxidase of myeloid cells, in the regulation of lymphocyte function with focus on ROS-induced dysfunction of natural killer (NK) cells and T lymphocytes in myeloid leukemia. In Paper I, a novel mechanism is presented by which specifically activated T lymphocytes evade inactivation by ROS after antigen presentation. LÄS MER