Sökning: "dexamethasone"

Visar resultat 1 - 5 av 119 avhandlingar innehållade ordet dexamethasone.

  1. 1. Mechanisms of Sensitization to Apoptosis in Multiple Myeloma

    Författare :Anna Hammarberg; Helena Jernberg Wiklund; Kenneth Nilsson; Federico Caligaris-Cappio; Uppsala universitet; []
    Nyckelord :Pathology; multiple myeloma; apoptosis; IGF-1; mTOR; IAP; GSK3; rapamycin; PPP; dexamethasone; CT99021; Patologi;

    Sammanfattning : Multiple myeloma (MM) is a hematological tumor of plasma blast/plasma cell origin heterogeneous with respect to the morphological differentiation stage of the tumor cells, genetic alterations and course of disease. A challenge in MM research is to overcome resistance to therapy, which inevitably arises. LÄS MER

  2. 2. Hormonal programming and adrenal function. Studies in children and in a rat model

    Författare :Jovanna Dahlgren; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Children; cortisol; dehydroepiandrosterone sulphate; small for gestational age; short stature; cytokines; dexamethasone; insulin sensitivity; androgenization;

    Sammanfattning : Prenatal events during specific time windows have been found to be followed by permanent changes affecting neuroendocrine, so called programming. Undernutrition, placental dysfunction or maternal stress, are apparent examples of such stimuli. LÄS MER

  3. 3. Mechanisms of therapy resistance in acute lymphoblastic leukemia

    Författare :Kinjal Shah; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALL; B-ALL; T-ALL; dexamethasone; FLT3; Signaling pathways; BCL2; resistance; PLK1; synergy;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) is a highly aggressive pediatric cancer that can affect both B cells and T cells. The advent of new therapies has increased the cure rates for both B-ALL and T-ALL patients. However, some patients still experience relapse with a variable response to the treatment and display poor survival. LÄS MER

  4. 4. Pathogenesis and treatment of chemical-induced lung injury

    Författare :Elisabeth Wigenstam; Anders Bucht; Thomas Sandström; Kjell Larsson; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chemical-induced lung injury; dexamethasone; melphalan; vitamin E; respiratory mechanics; lungmedicin; Lung Medicine;

    Sammanfattning : Inhalation of chemical substances can cause irritation to airways and in high doses acute airway injury. When mice are exposed to the alkylating nitrogen mustard analogue melphalan they develop an acute airway inflammation with a rapid influx of neutrophils to the lungs. LÄS MER

  5. 5. Depression after stroke

    Författare :Monica Åström; Rolf Adolfsson; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cerebrovascular disorders; stroke; depression; living conditions; life satisfaction; social network; dysphasia; self-care ability; cerebral atrophy; dexamethasone;

    Sammanfattning : Both stroke and depression are major health problems in the elderly. In this study, the prevalence of major depression after stroke was investigated in a well-defined sample of acute stroke patients (n=80), followed up at 3 months, 1 year, 2 and 3 years after the stroke event. Links to biological and psychosocial factors were examined. LÄS MER