Sökning: "leukocyte rolling"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden leukocyte rolling.

  1. 1. Endothelial-leukocyte interactions

    Författare :Maria Olofsson; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Histology; endothelial cell; leukocyte; apoptosis; mitochondria; heparin binding protein; vascular permeability; E-selectin; migration; rolling; cytochemistry; histochemistry; tissue culture; Histologi; cytokemi; histokemi; vävnadskultur;

    Sammanfattning : This thesis describes early inflammatory responses involving interactions between leukocytes and the endothelial lining of the blood vessel wall. An adhesion molecule, E-selectin, which is upregulated on interleukin-1 activated endothelium, was found to mediate rolling between leukocytes and endothelial cells in vivo. LÄS MER

  3. 2. Role of adhesion molecules and chemokines in TNF-alpha-induced leukocyte recruitment

    Författare :Xiao Wei Zhang; Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; intravital microscopy; microcirculation; inflammation; adhesion; leukocyte; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Sammanfattning : Migration of leukocytes from the circulating blood into the extravascular tissue is a key component in inflammatory reactions. Leukocyte extravasation (rolling-activation-adhesion-transmigration) is strictly coordinated by adhesion molecules and chemokines expressed on cell surfaces and in tissues. LÄS MER

  4. 3. Leukocyte rolling and firm adhesion in the microvasculature : functional significance for leukocyte recruitment in inflammation

    Författare :Xun Xie; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :adhesion molecules; blood flow; chemoattractants; endothelium; flowcytometry; fucoidin; heparin; inflammation; integrins; intravital microscopy; leukocyteadhesion; leukocyte extravasation; leukocyte rolling; meningitis; mesentery; microcirculation; ;

    Sammanfattning : Leukocyte recruitment to tissues is a key component in the inflammatory process. In order for circulating leukocytes to extravasate, they need to interact with vascular endothelium in several sequential steps. LÄS MER

  5. 4. On leukocyte recruitment in colonic ischemia-reperfusion

    Författare :Stefan Santén; Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Leukocyte recruitment is a rate-limiting step in inflammatory disease. Tissue accumulation of leukocytes is a multi-step process comprising leukocyte rolling, adhesion and transmigration across the vascular endothelium. LÄS MER

  7. 5. On leukocyte recruitment in endotoxemic liver injury

    Författare :Daniel Klintman; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ortopedi; traumatology; Kirurgi; orthopaedics; Surgery; Sepsis; Liver; Inflammation; Adhesion; Endotoxemia; traumatologi;

    Sammanfattning : Leukocyte recruitment is a key feature of liver injury associated with endotoxemia and systemic inflammation. The aim of this thesis was to define the adhesive mechanisms underlying leukocyte endothelial cell interactions, and the therapeutic potential of interference with specific adhesion molecules in endotoxemic liver damage. LÄS MER