Sökning: "high performance liquid chromatography"

Visar resultat 31 - 35 av 155 avhandlingar innehållade orden high performance liquid chromatography.

1. 31. New tools for sample preparation and instrumental analysis of dioxins in environmental samples

   Författare :Lan Do; Peter Haglund; Staffan Lundstedt; Eric Reiner; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PCDD Fs; dioxins; pressurized liquid extraction; PLE; selective SPLE; modular M-PLE; soil; sediment; sludge; gas chromatography; new stationary phases; multivariate data analysis; selectivity; interaction; Environmental Science; miljövetenskap;

   Sammanfattning : Polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), two groups of structurally related chlorinated aromatic hydrocarbons, are of high concern due to their global distribution and extreme toxicity. Since they occur at very low levels, their analysis is complex, challenging and hence there is a need for efficient, reliable and rapid alternative analytical methods. LÄS MER

3. 32. Progress of Weak Affinity Chromatography as a Tool in Drug Development

   Författare :Elinor Meiby; Sten Ohlson; Manfred Raida; Linnéuniversitetet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; weak affinity chromatography; fragment based drug discovery; fragment screening; thrombin; trypsin; cyclin G-associated kinase; Hsp90; Pin1; cyclooxygenase; lipodisks; Biokemi; Biochemistry;

   Sammanfattning : Weak Affinity Chromatography (WAC) is a technology that was developed to analyse weak (KD > 10-5 M) although selective interactions between biomolecules. The focus of this thesis was to develop this method for various applications in the drug development process.Fragment Based Drug Discovery is a new approach in finding new small molecular drugs. LÄS MER

4. 33. Evaluation of a Miniaturized Rotating Disk Apparatus for In Vitro Dissolution Rate Measurements in Aqueous Media : Correlation of In Vitro Dissolution Rate with Apparent Solubility

   Författare :Anita M. Persson; Curt Pettersson; Anders Sokolowski; Anders Karlsson; Alex Avdeef; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; analytical methods; HPLC high-performance liquid chromatography ; miniaturization; in vitro dissolution rate; apparent solubility; physicochemical properties; dissolution media; correlation study; chemometrics; Pharmaceutical chemistry; Farmaceutisk kemi; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

   Sammanfattning : The general aim of this thesis was to evaluate a newly designed and constructed miniaturized rotating disk apparatus for in vitro dissolution rate measurements of different drug substances from all of the classes in the Biopharmaceutical Classification System (BCS). The new equipment is based on a low volume flow-through cell of Plexiglas, a gold plated magnetic bar and a special designed press. LÄS MER

5. 34. From achiral to chiral analysis of citalopram

   Författare :Björn Carlsson; Yngve Bergqvist; Linköpings universitet; []
   Nyckelord :depression; noradrenaline; dopamine; serotonin; citalopram; selective serotonin-reuptake inhibitor SSRI ; high-performance liquid chromatography HPLC ; therapeutic drug monitoring TDM ; enantioselective separation; MEDICINE; MEDICIN;

   Sammanfattning : Within the field of depression the “monoamine hypothesis” has been the leading theory to explain the biological basis of depression. This theory proposes that the biological basis of depression is due to a deficiency in one or more of three key neurotransmitter systems, namely noradrenaline, dopamine and serotonin which are thought to mediate the therapeutic actions of virtually every known antidepressant agent. LÄS MER

7. 35. Dynamics of astaxanthin, tocopherol (Vitamin E) and thiamine (Vitamin B1) in the Baltic Sea ecosystem : Bottom-up effects in an aquatic food web

   Författare :Norbert Häubner; Pauli Snoeijs; Jon Ågren; Rhena Schumann; Markku Viitasalo; Uppsala universitet; []
   Nyckelord :Baltic Sea; carotenoids; astaxanthin; tocopherols; Vitamin E; thiamine; Vitamin B1; pelagic food web; eutrophication; M74; phytoplankton; zooplankton; sprat; Sprattus sprattus balticus; herring; Clupea harengus; salmon; Salmo salar; cod; Gadus morhua; High Performance Liquid Chromatography HPLC ; electrochemical detection ECD ;

   Sammanfattning : The thesis combines laboratory experiments and field expeditions to study production, transfer and consumption of non-enzymatic antioxidants and thiamine in an aquatic food web. In particular, I (1) documented spatial and seasonal variation of tocopherols and carotenoids in the Baltic Sea pelagic food web, and (2) examined the effects of abiotic and biotic factors on tocopherol, carotenoid and thiamine concentrations in phytoplankton, zooplankton and fish. LÄS MER