Sökning: "lipodisks"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet lipodisks.

  1. 1. Progress of Weak Affinity Chromatography as a Tool in Drug Development

    Författare :Elinor Meiby; Sten Ohlson; Manfred Raida; Linnéuniversitetet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; weak affinity chromatography; fragment based drug discovery; fragment screening; thrombin; trypsin; cyclin G-associated kinase; Hsp90; Pin1; cyclooxygenase; lipodisks; Biokemi; Biochemistry;

    Sammanfattning : Weak Affinity Chromatography (WAC) is a technology that was developed to analyse weak (KD > 10-5 M) although selective interactions between biomolecules. The focus of this thesis was to develop this method for various applications in the drug development process.Fragment Based Drug Discovery is a new approach in finding new small molecular drugs. LÄS MER

  3. 2. Searching for Synergy : Radiosensitization of 177Lu-DOTATATE

    Författare :Sara Lundsten; Marika Nestor; Hanna Björkelund; Katarina Edwards; Julie Nonnekens; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; targeted radionuclide therapy; radiosensitization; p53; MDM2 MDM4 inhibition; HSP90; drug synergy; drug delivery; lipid nanoparticles; lipodisks; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : Cancers presents a major health challenge, and there is a pressing need to develop new therapeutic strategies. Surgery, chemotherapy and radiation are the most commonly used treatments for cancer today. Radiation can be given as targeted radionuclide therapy (TRT), i.e. LÄS MER

  4. 3. Effects of gangliosides and PEG-lipids on the structure, properties and interactions of lipid self-assemblies

    Författare :Philipp Grad; Katarina Edwards; Marité Cárdenas; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Lipid self-assemblies; solution-solid interface; liposomes; lipodisks; lipid bilayers; liposome permeability; cuvettes;

    Sammanfattning : When developing or utilizing lipid-based nanocarriers detailed structural characterization of the lipid self-assemblies, as well as in depth knowledge and control of their interaction with solids materials, is necessary to understand the behaviour. Disregarding one of the parameters can lead to misinterpretation of the results due to non-uniform samples or experimental artifacts caused by undesirable interactions with solid surfaces. LÄS MER

  5. 4. Studying the influence of the physicochemical properties of lipid nanoparticles for mucosal vaccine delivery

    Författare :Karin Norling; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; influenza; nanoparticles; CTA1-DD; liposomes; dendritic cells; lipodisks; antigen presentation; flow cytometry; vaccine carriers; TIRF microscopy;

    Sammanfattning : Lipid-based nanoparticles have attracted attention as promising pharmaceutical carriers. Reports of them having inherent adjuvant properties make them particularly interesting as vaccine vectors; however, the physicochemical profile of an ideal nanoparticle for mucosal vaccine delivery remains unknown. LÄS MER

  7. 5. Development of lipodisks as carriers for cationic amphiphilic peptides

    Författare :Karin Reijmar Brunnström; Katarina Edwards; Fredrik Höök; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Antibiotics have made a tremendous contribution to mankind. They are one of the most successful medicines in human history. However, more and more bacterial strains develop resistance and the risk to public health can hardly be overstated. New types of antibiotics are urgently needed. LÄS MER