Sökning: "high performance liquid chromatography"

Visar resultat 21 - 25 av 155 avhandlingar innehållade orden high performance liquid chromatography.

1. 21. Development of Sheathless Electrospray Mass Spectrometry and Investigations of Associated Electrochemical Processes – A Fairy Tale

   Författare :Stefan Nilsson; Karin Markides; Leif Nyholm; Jonas Bergquist; Per Andrén; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; electrospray; sheathless; mass spectrometry; capillary electrophoresis; electrochemistry; chromatography; interface; fairy dust; gold; Analytisk kemi; Analytical chemistry; Analytisk kemi;

   Sammanfattning : In microscale separations, such as capillary electrophoresis and -liquid chromatography, the liquid flow rates are in the order of nanoliters per second. If such flow rates are to be interfaced with a mass spectrometer (MS) using electrospray (ES) ionization, without loss of separation efficiency, each fraction of the analyte zone must remain undisturbed by the high voltage contact necessary for ES. LÄS MER

3. 22. Advances in analytical methodologies for studies of the platinum metallome in malignant cells exposed to cisplatin

   Författare :Yvonne Nygren; Erik Björn; Knut Irgum; Bente Gammelgaard; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Method development; Metallome; Inductively coupled plasma mass spectrometry; Electrospray ionization mass spectrometry; Liquid chromatography; Hyphenation; Organic modifier; Cisplatin; Platinum; Analytical chemistry; Analytisk kemi; analytisk kemi; Analytical Chemistry;

   Sammanfattning : The scientific progress about the important chemotherapeutic drug substance cisplatin (CDDP) and its function has often been rendered by data difficult to interpret, and still many questions about its mode of action remains to be clarified by the scientific community. However, studies of CDDP possess a high complexity due to; i) low intracellular concentration, ii) many potential biomolecule targets, iii) poor or unknown stability of the intact drug and its biomolecule adducts and iv) complex and varying sample matrices. LÄS MER

4. 23. Characterization of Molecular Adsorption Using Liquid Chromatography and Mass Spectrometry

   Författare :Torgny Undin; Andreas Dahlin; Sara Bergström Lind; Jonas Bergquist; Elsa Lundanes; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

   Sammanfattning : Molecular adsorption is a key feature in several disciplines of chemistry, covering as diverse fields as chromatographic separation to biomaterial development. This thesis aims at developing methods and techniques for the characterization of molecular adsorption at the liquid-solid interface. LÄS MER

5. 24. Method Development in Quantitative and Structural Proteomics using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

   Författare :Charlotte Hagman; Per Håkansson; Jonas Bergquist; Jos Buijs; Michael Przybylski; Uppsala universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Biotechnology; Cerebrospinal Fluid; Electrospray Ionization; Fourier Transform Ion Cyclotron Resonance Mass Spectrometry; Global Markers; High Performance Liquid Chromatography; Gas-Phase Exchange; Hydrogen Deuterium Exchange; Plasma; Protoemics; Quantification; Structural Elucidation; Bioteknik; Bioengineering; Bioteknik;

   Sammanfattning : In this thesis, methods for studying different aspects of proteomics were developed with Fourier Transform Ion Cyclotron Resonance, (FTICR), mass spectrometry. The FTICR technique provides ultra-high mass resolving power, mass accuracy at sub ppm level and sensitivity in the attomole region. LÄS MER

7. 25. Analysis of Degradation Products from Wood and Methods for Detoxification of Lignocellulose Hydrolysates

   Författare :Per Persson; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; galactoglucomannan; mass spectrometry; liquid chromatography; sugar degradation; detoxification; fermentation inhibitors; lignocellulose hydrolysates; Ethanol production; softwood; Analytical chemistry; Analytisk kemi; countercurrent supercritical fluid extraction;

   Sammanfattning : In order to produce fuel ethanol from lignocellulose, it is necessary to hydrolyse the sugar-containing constituents hemicellulose and cellulose. During acid hydrolysis, a number of compounds are formed or liberated in addition to the fermentable monomeric sugars. LÄS MER