Sökning: "conformational changes"

Visar resultat 26 - 30 av 196 avhandlingar innehållade orden conformational changes.

  1. 26. Conformational and Dynamical Aspects of Conjugated Polymers and Oligomers of Interest for Photoluminescence

    Författare :Mette Grage; Kemisk fysik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; femtosecond spectroscopy; conformations; anisotropy; excitation transfer; oligothiophene radical cations; MEH-PPV; Conjugated polymers; polythiophene; resonance Raman spectroscopy.; Chemistry; Kemi; Physics; Fysik;

    Sammanfattning : Transient absorption laser spectroscopy and resonance Raman spectrscopy have been used to study conjugated polymers and oligomers. To extract more information the measurements have been compared to computer simulations and calculations. LÄS MER

  3. 27. A Chloroplast Localized Small Heat Shock Protein, Hsp21. Importance of Hsp21 in stress protection of transgenic Arabidopsis thaliana, recombinant expression and characterization of oxidation-dependent conformational changes

    Författare :Ulrika Härndahl; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; a-crystallin; sHsp; chaperone; amphipathic a-helix; oligomer; redox-regulated; methionine sulfoxidation; oxidative stress; regulation; protein structure; circular dichroism; mass spectrometry; fluorescence spectroscopy; Biochemistry; Metabolism; Biokemi;

    Sammanfattning : A specific group of heat shock proteins, the so called small heat shock proteins (sHsps), exists in all organisms but are especially abundant in plants. The sHsps prevent aggregation of other proteins (substrate proteins) during transient heat and oxidative stress. LÄS MER

  4. 28. Biophysical characterization of protein-protein interactions involving intrinsically disordered proteins

    Författare :Ida Nyqvist; Jakob Dogan; Ivarsson Ylva; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Intrinsically disordered proteins; Protein-protein interactions; Disorder-to-order transition; Rate-limiting transition state; Ф-value analysis; NMR relaxation; Side-chain dynamics; Backbone dynamics; Conformational entropy change; Biophysics; biofysik;

    Sammanfattning : Intrinsically disordered proteins and regions (IDPs/Rs) are proteins that do not form stable and well-defined structures in their free states but rather occupy an ensemble of conformations that change over time while still staying functional. They are prevalent in the eukaryotic proteome and are involved in various vital processes in the cell where they often interact with their binding partners through coupled binding and folding reactions. LÄS MER

  5. 29. Simulating Functional Cycles and Drug Modulation in Ligand-gated Ion Channels

    Författare :Yuxuan Zhuang; Erik Lindahl; Grace Brannigan; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ion channels; molecular dynamics; markov state model; lipid modulation; nicotinic receptor; protein conformational transitions; Biophysics; biofysik;

    Sammanfattning : Understanding the intricate motions and conformational changes that govern biological processes remains a fascinating and challenging endeavor. The research presented in this thesis aims to elucidate the dynamic processes underlying biological functions, specifically focusing on the dynamics of pentameric ligand-gated ion channels (pLGICs), which play a crucial role in signal transduction within the brain. LÄS MER

  7. 30. Molecular basis of estrogen receptor antagonism

    Författare :Nina Heldring; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Estrogen Receptor; antagonism; receptor signaling; phytoestrogen and conformational changes;

    Sammanfattning : Estrogen Receptors (ERs), ERα and ERβ, are responsible for mediating the physiological effects of the steroid hormone 17b-estradiol and structurally related compounds. ER signaling is a complex process where the combined effects of accessory proteins, known as coregulators, promoter characteristics and influence from other signaling systems, determine the cell-specific transcriptional response in a given situation. LÄS MER