Sökning: "conformational changes"

Visar resultat 41 - 45 av 196 avhandlingar innehållade orden conformational changes.

  1. 41. The impact of protein modification on immunogenicity and arthritogenicity

    Författare :Ewa Westman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Post translational modifications; chlorination; CII; CIA; RA; effect of therapeutic substance CDM for RA;

    Sammanfattning : Rheumatoid arthritis (RA) is an inflammatory autoimmune disease affecting about 1% of the Western world population. There are several theories regarding the etiopathogenesis. LÄS MER

  3. 42. Disordered matter: From Ionic Glasses to Proteins

    Författare :Charbel Tengroth; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; liquid-glass transition; PPG; disorder; B2O3; neutron scattering; hemoglobin; time-resolved resonance Raman scattering; CKN;

    Sammanfattning : Understanding the glassy state is regarded as one of the ten most important questions in physics in the 21st century [1]. This thesis deals with structure and dynamics of a few model disordered systems ranging from an ionic glass to proteins. The structure of an ionic liquid, Ca0.4K0. LÄS MER

  4. 43. Modelling the Protein-DNA Interface

    Författare :Malin Lüking; Shina C. Lynn Kamerlin; Ehmke Pohl; Uppsala universitet; []
    Nyckelord :Protein-DNA interactions; Molecular Dynamics; Coarse-grained simulations; gene regulation; Biokemi; Biochemistry;

    Sammanfattning : Protein-DNA interactions are crucial to life. Several millions of DNA base pair steps are organ- ised, read and protected by proteins in every cell. Protein-DNA interactions must be specific, controllable and reasonably fast. Understanding how these features coexist is one of the great challenges for biochemists and molecular biologists. LÄS MER

  5. 44. Intermediate State Stabilisation in Enzyme Catalysis Structural studies of two serine proteases and a photosynthetic reaction centre

    Författare :Gergely Katona; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; photosynthetic reaction centre; X-ray crystallography; structural mechanism; enzyme kinetics; serine protease; enzyme intermediate; enzyme catalysis;

    Sammanfattning : Enzymes play a key role in every organisms life. They catalyse chemical reactions and may also respond to external stimulus. The reoccurring theme of this thesis is how biologically relevant information can be gleaned from X-ray structures of the enzymes. LÄS MER

  7. 45. Active Transport of Ions across Biomembranes : A Kinetic Study of Cytochrome c Oxidase Reconstituted into Phospholipid Vesicles

    Författare :Kristina Faxén; Peter Brzezinski; Pia Ädelroth; Thomas E. DeCoursey; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cytochrome c oxidase; electron transfer; proton transfer; proton pumping; kinetic isotop effect; ion pumping; flow flash; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Ion transport across membranes is of uttermost importance for us. It is the foundation for signaling of various kinds e.g. in the nerve-system. LÄS MER