Sökning: "Disorder-to-order transition"
Hittade 3 avhandlingar innehållade orden Disorder-to-order transition.
1. Biophysical characterization of protein-protein interactions involving intrinsically disordered proteins
Sammanfattning : Intrinsically disordered proteins and regions (IDPs/Rs) are proteins that do not form stable and well-defined structures in their free states but rather occupy an ensemble of conformations that change over time while still staying functional. They are prevalent in the eukaryotic proteome and are involved in various vital processes in the cell where they often interact with their binding partners through coupled binding and folding reactions. LÄS MER
2. Regulation of the multi-functional protein YscU in assembly of the Yersinia type III secretion injectisome
Sammanfattning : Yersinia pseudotuberculosis is a Gram-negative zoonotic pathogenic bacterium causing gastroenteritis in human and animals. It shares a conserved virulence plasmid encoding for a needle-like secretion machinery, or type III secretion system, which can be found in other pathogenic Gram-negative bacteria. LÄS MER
3. Characterization and Engineering of Protein-Protein Interactions Involving PDZ Domains
Sammanfattning : The work presented in this thesis has contributed with knowledge to several aspects of protein-protein interaction involving PDZ domains. A substantial amount of our proteome contains regions that are intrinsically disordered but fold upon ligand interaction. LÄS MER