Sökning: "basic assumptions"

Visar resultat 11 - 15 av 117 avhandlingar innehållade orden basic assumptions.

  1. 11. Methodological Studies on Covariate Model Building in Population Pharmacokinetic-Pharmacodynamic Analysis

    Författare :Ulrika Wählby; Thomas Ludden; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Sammanfattning : Population pharmacokinetic (PK) – pharmacodynamic (PD) modelling, using nonlinear mixed effects models, is increasingly being applied to obtain PK-PD information in drug development. Covariate modelling, the establishment of relationships between model parameters and patient characteristics, is undertaken to explain PK-PD variability and facilitate dose adjustment decisions, and is consequently an important objective of population PK-PD. LÄS MER

  3. 12. Pharmacometric Methods and Novel Models for Discrete Data

    Författare :Elodie L Plan; Mats O Karlsson; Laura Sargentini-Maier; Armel Stockis; Christian Laveille; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; pharmacodynamics; disease progression; modelling; discrete data; count; ordered categorical; repeated time-to-event; RTTCE; RCEpT; NONMEM; FOCE; LAPLACE; SAEM; AGQ; pain scores; epilepsy seizures; gastroesophageal symptoms; statistical power; simulations; diagnostics; PHARMACY; FARMACI; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : Pharmacodynamic processes and disease progression are increasingly characterized with pharmacometric models. However, modelling options for discrete-type responses remain limited, although these response variables are commonly encountered clinical endpoints. Types of data defined as discrete data are generally ordinal, e.g. LÄS MER

  4. 13. Spontaneous reporting of adverse drug reactions : Possibilities and limitations

    Författare :Martin Bäckström; Tom Mjörndal; Rune Dahlqvist; Folke Sjökvist; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; adverse drug reactions; spontaneous reporting; metamizole; general practitioners; hospital physicians; under-reporting; economical inducement; nurses.; Farmakologi; Pharmacological research; Farmakologisk forskning; Clinical Pharmacology; klinisk farmakologi;

    Sammanfattning : Adverse drug reactions (ADRs) constitute a major problem in society and in drug therapy. They are a common cause of short-term hospitalization, prolonged hospitalization and death. Spontaneous reporting of ADRs remains one the most effective methods for detecting new and serious drug reactions. LÄS MER

  5. 14. Assumptions of retail price strategy and price tactic decisions

    Författare :Madelen Lagin; Högskolan Dalarna; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Complex Systems – Microdata Analysis; Komplexa system - mikrodataanalys;

    Sammanfattning : This licentiate thesis sets out to analyse how a retail price decision frame can be understood. It is argued that it is possible to view price determination within retailing by determining the level of rationality and using behavioural theories. LÄS MER

  7. 15. Kunskapsbildning mellan träindustri och akademi : en studie av dess förutsättningar och möjligheter

    Författare :Johan Palm; Thomas Thörnqvist; Lena Fritzén; Leif Jonsson; Växjö universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Research collaboration; Joint research; Knowledge development; Theory and practice; Participatory observation; Wood timber industry.; Forskningssamverkan; Kunskapsbildning; Teori och praktik; Deltagande observation; Träindustri. Tekniköverföring; Samverkan industri och akademi.; INTERDISCIPLINARY RESEARCH AREAS; TVÄRVETENSKAPLIGA FORSKNINGSOMRÅDEN;

    Sammanfattning : Small and medium-sized enterprises badly need new knowledge. Their need is constantly increasing due to the market demand for custom-designed products, which means companies must be more flexible. Wood processing companies are having difficulty establishing contact with academia in order to meet this need. LÄS MER