Sökning: "adipose-derived stem cells"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden adipose-derived stem cells.

1. 1. Keratinocytes and Adipose-derived mesenchymal stem cells : The heir and the spare to regenerative cellular therapies for difficult-to-heal skin wounds

   Författare :Hady Shahin; Ahmed Taher Elserafy; Moustafa Elmasry; Folke Sjöberg; Ingrid Steinvall; Daniel Nowinski; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Keratinocytes; ATMP; Bio-production; Adipose-derived mesenchymal stem cells; Wound healing;

   Sammanfattning : Cell-based therapy is considered as Advanced Therapy Medicinal Product, (ATMP), which had increasingly stricter regulations in the last decade. The cells must be produced according to the ‘Guidelines on Good Manufacturing Practice (GMP) specific to Advanced Therapy Medicinal Products’, adopted by the European Medicines Agency (EMA). LÄS MER

3. 2. The use of adipose derived stem cells in spinal cord and peripheral nerve repair

   Författare :Mallappa K Kolar; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; spinal cord injury; peripheral nerve injury; adipose derived stem cells; regeneration; neurotrophic factor; angiogenic factor;

   Sammanfattning : Clinically, injuries affecting the spinal cord or peripheral nerves can leave those affected with severe disability and, at present, there are limited options for treatment. Peripheral nerve injury with a significant gap between the proximal and distal stumps is currently treated with autologous nerve grafting but this is limited by availability of donor nerve and has associated morbidities. LÄS MER

4. 3. Pancreatic extracellular communication. Applications to beta cell cultures and islet amyloid polypeptide aggregation

   Författare :Diana Ribeiro; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in vitro pancreatic models; induced pluripotent stem cells; stem cell differentiation; insulin; 3D-culture; extracellular vesicles; glucose-stimulated insulin secretion; islet amyloid polypeptide; type 2 diabetes mellitus; extracellular matrix; adipose-derived stem cells; Diabetes mellitus; protein aggregation;

   Sammanfattning : Diabetes mellitus (DM) is a disease with epidemic proportions due to increased incidences worldwide, persistence of undiagnosed cases, uncontrolled forms of the disease, association with cardiovascular complications, and lack of definitive treatment options. In particular, type 2 DM (T2DM) is placing an enormous financial burden on worldwide healthcare systems that will increase in the futureThere is a need to develop physiological assay platforms that provide functionally relevant models of diabetes in order to accelerate the discovery of new treatments. LÄS MER

5. 4. Stem cells for nerve repair and prevention of muscle atrophy

   Författare :Dominique Schaakxs; Paul Kingham; Mikael Wiberg; Daniel Kalbermatten; Christine Radtke; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipose stem cells; biomaterial; muscle; nerve injury; neuromuscular junction; regeneration; cell research; cellforskning; Medical Cell Biology; medicinsk cellbiologi;

   Sammanfattning :   Peripheral nerve injury (PNI) is common and despite modern microsurgical techniques of repair, functional restoration is always incomplete. This results in impaired sensation and reduced motor function alongside pain and cold intolerance. LÄS MER

7. 5. Nerve gap repair by the use of artificial conduits and cultured cells

   Författare :Daniel Kalbermatten; Mikael Wiberg; Ulrich Mennen; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipose stem cells; cell matrix; fibrin; nerve conduit; nerve gap; Surgery; Kirurgi; kirurgi; Surgery;

   Sammanfattning : Peripheral nerve injuries are often associated with loss of nerve tissue and require autologous nerve grafts to provide a physical substrate for axonal growth. This thesis investigates the use of fibrin as both a tubular conduit to guide nerve regeneration and also as a matrix material to suspend various regenerative cell types within/on poly-3-hydroxybutyrate (PHB) nerve conduits. LÄS MER