Sökning: "Paul Kingham"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Paul Kingham.
1. Cell therapy for denervated tissue
Sammanfattning : Background: Peripheral nerve injury results in denervation of tendons and muscles. The biology of denervated muscle has been well studied but little is known about the associated tendons. LÄS MER
2. Transplantation of mesenchymal stem cells and injections of microRNA as therapeutics for nervous system repair
Sammanfattning : Traumatic injuries to the spinal cord (SCI) and peripheral nerve (PNI) affect several thousand people worldwide every year. At present, there is no effective treatment for SCI and despite continuous improvements in microsurgical reconstructive techniques for PNI, many patients are still left with permanent, devastating neurological dysfunction. LÄS MER
3. Optimizing stem cells for reconstructive surgery
Sammanfattning : Fat grafting has become an established method in plastic surgery for treating soft tissue defects. The results for survival of the fat being transplanted is unpredictable and supplementation of the graft with the Stromal Vascular Fraction (SVF) or cultures Adipose tissue-derived stem cells (ASCs) can enhance graft viability. LÄS MER
4. Development and optimization of a 3D in vitro model for osteogenic biomaterial evaluation
Sammanfattning : Despite the innate regenerative capabilities of bone tissue, self-repair is impaired when an injury exceeds the critical size threshold because of trauma, congenital, or pathological conditions. Autologous transplantation is the gold standard to reconstruct large bone defects. LÄS MER
5. Stem cells for nerve repair and prevention of muscle atrophy
Sammanfattning : Peripheral nerve injury (PNI) is common and despite modern microsurgical techniques of repair, functional restoration is always incomplete. This results in impaired sensation and reduced motor function alongside pain and cold intolerance. LÄS MER