Sökning: "adenosine kinase"

Visar resultat 6 - 10 av 41 avhandlingar innehållade orden adenosine kinase.

  1. 6. Salvage and de novo synthesis of nucleotides in Trypanosoma brucei and mammalian cells

    Författare :Artur Fijolek; Lars Thelander; Arne Holmgren; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; nucleotides; ribonucleotide reductase; Ara-A; p53R2; Trypanosoma brucei; African sleeping sickness; trypanosomiasis; CTP synthetase; adenosine kinase; acivicin; adenine arabinoside; Biochemistry; Biokemi;

    Sammanfattning : All living cells are dependent on nucleic acids for their survival. The genetic information stored in DNA is translated into functional proteins via a messenger molecule, the ribonucleic acid (RNA). Since DNA and RNA can be considered as polymers of nucleotides (NTPs), balanced pools of NTPs are crucial to nucleic acid synthesis and repair. LÄS MER

  3. 7. DNA precursor biosynthesis-allosteric regulation and medical applications

    Författare :Reza Rofougaran; Anders Hofer; Thomas Borén; Staffan Eriksson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; DNA biosynthesis; ribonucleotide reductase; allosteric regulation; Trypanosoma brucei; adenosine kinase; nucleoside analogs; mitochondrial DNA; TWINKLE; Biokemi; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Ribonucleotide reductase (RNR) is a key enzyme for de novo dNTP biosynthesis. We have studied nucleotide-dependent oligomerization of the allosterically regulated mammalian RNR using a mass spectrometry–related technique called Gas-phase Electrophoretic Mobility Macromolecule Analysis (GEMMA). LÄS MER

  4. 8. Modulation of neutrophil extracellular trap formation in health and disease

    Författare :Ava Hosseinzadeh; Constantin F. Urban; Carol Munro; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophils; Candida albicans; Adenosine; Tempol; Nicotine; molekylärbiologi; Molecular Biology;

    Sammanfattning : The critical prompt innate immune response is highly built upon the influx of neutrophils from the blood stream to the site of infection. In the battlefield, neutrophils sense pathogen-associated molecular patterns (PAMPs) through their pattern-recognition receptors (PRRs) to launch a number of responses with the goal to defeat the invading pathogen. LÄS MER

  5. 9. Structure-Function Studies of Enzymes from Ribose Metabolism

    Författare :C. Evalena Andersson; Sherry Mowbray; Phil Evans; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; activation; isomerase; kinase; potassium; product inhibition; ribose; ribose 5-phosphate; x-ray crystallography; enzyme kinetics; fluorescence spectroscopy; protein structure; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : In the pentose phosphate pathway, carbohydrates such as glucose and ribose are degraded with production of reductive power and energy. Another important function is to produce essential pentoses, such as ribose 5-phosphate, which later can be used in biosynthesis of nucleic acids and cofactors. LÄS MER

  7. 10. Structure determination of Methanocaldococcus jannaschii nucleoside kinase

    Författare :Linda Arnfors; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Methanocaldococcus jannaschii; Archaea; hyperthermophile; nucleoside kinase; ribokinase family; X-ray crystallography; differential scanning calorimetry; thermal stability;

    Sammanfattning : All organisms can be divided into the tree kingdoms of life: Archaea, Bacteria and Eukarya. Archaeal organisms are often found to exhibit, compared to human perspectives, extreme environments, such as high temperature, high salt and acidic habitats. Many archaeal species are hyperthermophiles, i.e. LÄS MER