Sökning: "Arne Holmgren"
Hittade 3 avhandlingar innehållade orden Arne Holmgren.
1. Salvage and de novo synthesis of nucleotides in Trypanosoma brucei and mammalian cells
Sammanfattning : All living cells are dependent on nucleic acids for their survival. The genetic information stored in DNA is translated into functional proteins via a messenger molecule, the ribonucleic acid (RNA). Since DNA and RNA can be considered as polymers of nucleotides (NTPs), balanced pools of NTPs are crucial to nucleic acid synthesis and repair. LÄS MER
2. Class I Ribonucleotide Reductases : overall activity regulation, oligomerization, and drug targeting
Sammanfattning : Ribonucleotide reductase (RNR) is a key enzyme in the de novo biosynthesis and homeostatic maintenance of all four DNA building blocks by being able to make deoxyribonucleotides from the corresponding ribonucleotides. It is important for the cell to control the production of a balanced supply of the dNTPs to minimize misincorporations in DNA. LÄS MER
3. Targeting the nucleotide metabolism of the mammalian pathogen Trypanosoma brucei
Sammanfattning : Trypanosoma brucei causes African sleeping sickness in humans and Nagana in cattle. There are no vaccines available against the disease and the current treatment is also not satisfactory because of inefficacy and numerous side effects of the used drugs.T. LÄS MER