Sökning: "adenosine kinase"

Visar resultat 16 - 20 av 41 avhandlingar innehållade orden adenosine kinase.

  1. 16. Targets and strategies for drug development against human African sleeping sickness

    Författare :Farahnaz Ranjbarian; Anders Hofer; Staffan G. Svärd; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T. brucei thymidine kinase; T. brucei methylthioadenosine phosphorylase; FANA-A purine nucleoside analogues; essential oils;

    Sammanfattning : Trypanosoma brucei is a causative agent of African sleeping sickness. It is an extracellular parasite which circulates in the blood, lymph and eventually invades the central nervous system. LÄS MER

  3. 17. Regulation of signal transduction in the striatum by typical and atypical antipsychotic drugs

    Författare :Kerstin Håkansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adenosine A2A receptor; basal ganglia; cAMP-dependent protein kinase; clozapine; DARPP-32; dopamine D 2 receptor; extracellular signal-regulated protein kinases 1 and 2; extrapyramidal side effects; glutamate AMPA receptor; haloperidol; knockout mouse; phosphorylation; schizophrenia; tyrosine hydroxylase.;

    Sammanfattning : The only effective therapy for schizophrenia is based on the use of antipsychotic drugs. These substances act as dopamine D 2 receptor antagonists and can be classified as typical or atypical. Typical antipsychotics, e.g. LÄS MER

  4. 18. Regulation of Human Papillomavirus Type 16 Early and Late Gene Expression

    Författare :Haoran Yu; Avdelningen för medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HPV16; mRNA; Splicing; gene expression;

    Sammanfattning : Human papillomavirus type 16 (HPV16) is a cancer-causing virus that contributes to at least 70% of cervical cancer as well as to other anogenital cancers and head and neck cancer. Understanding HPV16 gene regulation is important to enhance our understanding of HPV16 infections and may contribute to development of antiviral drugs. LÄS MER

  5. 19. Insulin signal transduction in skeletal muscle : special consideration for insulin resistance and diabetes

    Författare :Xiao Mei Song; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :exercise; fiber-type; glucose transport; hyperglycemia; obesity; signal transduction; skeletal muscle; NIDDM;

    Sammanfattning : This dissertation work is focused on the insulin-signal-transduction pathways to glucose transport in skeletal muscle from animal models of NIDDM. The overall objective is to determine the effectiveness of different pharmacological treatments to improve insulin action in skeletal muscle. LÄS MER

  7. 20. L-DOPA-induced signaling pathways and neuroepigenetic mechanisms in experimental parkinsonism and dyskinesia

    Författare :Michael Feyder; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In patients with Parkinson’s disease (PD), the restoration of depleted striatal dopamine by chronic administration of its precursor, L-DOPA, results in the emergence of debilitating involuntary movements. This complication, termed L-DOPA-induced dyskinesia (LID), represents a limitation to the most efficacious treatment for PD motor symptoms. LÄS MER