Sökning: "ribose 5-phosphate"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden ribose 5-phosphate.

  1. 1. Structure-Function Studies of Enzymes from Ribose Metabolism

    Författare :C. Evalena Andersson; Sherry Mowbray; Phil Evans; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; activation; isomerase; kinase; potassium; product inhibition; ribose; ribose 5-phosphate; x-ray crystallography; enzyme kinetics; fluorescence spectroscopy; protein structure; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : In the pentose phosphate pathway, carbohydrates such as glucose and ribose are degraded with production of reductive power and energy. Another important function is to produce essential pentoses, such as ribose 5-phosphate, which later can be used in biosynthesis of nucleic acids and cofactors. LÄS MER

  3. 2. Structural and Functional Studies of Ribose-5-phosphate isomerase B

    Författare :Annette K. Roos; Sherry L. Mowbray; Torsten Unge; Constance Jeffery; Uppsala universitet; []
    Nyckelord :Molecular biology; Mycobacterium tuberculosis; reaction mechanism; cis-enediolate high energy intermediate; allose-6-phosphate isomerase; rare sugar; pentose phosphate pathway; Rv2465c; X-ray crystallography; Molekylärbiologi;

    Sammanfattning : Ribose 5-phosphate isomerase (Rpi) is one of the major enzymes of the pentose phosphate pathway, where it catalyses the inter-conversion of ribose 5-phosphate (R5P) and ribulose 5-phosphate. Two forms of this isomerase with no significant amino acid sequence similarity exist, RpiA and RpiB. LÄS MER

  4. 3. A structural study of ribokinase from Escherichia coli

    Författare :Jill A. Sigrell; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; ATP-binding; conformational changes; kinase; ribose; X-ray crystallography; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Ribokinase phosphorylates the abundant sugar ribose, using ATP in the presence of magnesium. The phosphorylation is the first reaction in ribose metabolism and the product, ribose-5-phosphate, can enter the pentose phosphate pathway and glycolysis. It can also be used in the synthesis of histidine and purines. LÄS MER

  5. 4. Structure-Based Virtual Screening : New Methods and Applications in Infectious Diseases

    Författare :Micael Jacobsson; Anders Karlén; Mats Kihlén; Antti Poso; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; : drug discovery; docking; scoring; virtual screening; malaria; tuberculosis; Pharmaceutical chemistry; Läkemedelskemi;

    Sammanfattning : A drug discovery project typically starts with a pharmacological hypothesis: that the modulation of a specific molecular biological mechanism would be beneficial in the treatment of the targeted disease. In a small-molecule project, the next step is to identify hits, i.e. molecules that can effect this modulation. LÄS MER

  7. 5. Myocardial energy metabolism in ischemic preconditioning, role of adenosine catabolism

    Författare :Mohammad Kavianipour; Umeå universitet; []
    Nyckelord :Ischemic preconditioning; adenosine; purine nucleoside phosphorylase; microdialysis; pig; Medicine; medicin;

    Sammanfattning : Brief episodes of ischemia and reperfusion render the myocardium more resistant to necrosis from a subsequent, otherwise lethal ischemic insult. This phenomenon is called ischemic preconditioning(IP). LÄS MER