Sökning: "ribose"

Visar resultat 1 - 5 av 47 avhandlingar innehållade ordet ribose.

  1. 1. Structure-Function Studies of Enzymes from Ribose Metabolism

    Författare :C. Evalena Andersson; Sherry Mowbray; Phil Evans; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; activation; isomerase; kinase; potassium; product inhibition; ribose; ribose 5-phosphate; x-ray crystallography; enzyme kinetics; fluorescence spectroscopy; protein structure; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : In the pentose phosphate pathway, carbohydrates such as glucose and ribose are degraded with production of reductive power and energy. Another important function is to produce essential pentoses, such as ribose 5-phosphate, which later can be used in biosynthesis of nucleic acids and cofactors. LÄS MER

  3. 2. A structural study of ribokinase from Escherichia coli

    Författare :Jill A. Sigrell; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; ATP-binding; conformational changes; kinase; ribose; X-ray crystallography; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Ribokinase phosphorylates the abundant sugar ribose, using ATP in the presence of magnesium. The phosphorylation is the first reaction in ribose metabolism and the product, ribose-5-phosphate, can enter the pentose phosphate pathway and glycolysis. It can also be used in the synthesis of histidine and purines. LÄS MER

  4. 3. Structural and Functional Studies of Ribose-5-phosphate isomerase B

    Författare :Annette K. Roos; Sherry L. Mowbray; Torsten Unge; Constance Jeffery; Uppsala universitet; []
    Nyckelord :Molecular biology; Mycobacterium tuberculosis; reaction mechanism; cis-enediolate high energy intermediate; allose-6-phosphate isomerase; rare sugar; pentose phosphate pathway; Rv2465c; X-ray crystallography; Molekylärbiologi;

    Sammanfattning : Ribose 5-phosphate isomerase (Rpi) is one of the major enzymes of the pentose phosphate pathway, where it catalyses the inter-conversion of ribose 5-phosphate (R5P) and ribulose 5-phosphate. Two forms of this isomerase with no significant amino acid sequence similarity exist, RpiA and RpiB. LÄS MER

  5. 4. Apoptosis And Excitotoxicity In The Death of Cultured And Grafted Dopaminergic Neurones

    Författare :Gabriele Schierle; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ac-YVAD-cmk; MK-801; flunarizine; N-methyl-D-aspartate; voltage-dependent calcium channels; Bcl-2; caspase; excitotoxicity; apoptosis; tyrosine hydroxylase; dopamine; Parkinson s disease; intracerebral transplantation; Poly ADP-ribose polymerase; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Over the past two decades, grafting of embryonic nigral tissue has developed into a feasible therapeutic strategy for Parkinson's disease (PD). It has become apparent that the degree of restoration of dopaminergic neurotransmission by the transplanted cells is highly correlated to the symptomatic relief. LÄS MER

  7. 5. High-resolution phenotypic profiling of a eukaryotic ribosome

    Författare :Jonathan Esguerra; Göteborgs universitet; []
    Nyckelord :ribosome; ribosomal protein genes; box C D snoRNA; box H ACA snoRNA; 2’-O-ribose methylation; pseudouridylation; high-resolution phenotypic profiling; chemogenetic profiling; Saccharomyces cerevisiae; rRNA modification;

    Sammanfattning : All living cells contain ribosomes, complex macromolecular assemblies of ribonucleic acid (RNA) and proteins, responsible for synthesizing polypeptides in a process called translation. High-resolution three-dimensional ribosomal structures coupled with biochemical studies have paved the way in understanding the various mechanistic events during protein synthesis. LÄS MER