Sökning: "TRPV1"
Visar resultat 11 - 15 av 29 avhandlingar innehållade ordet TRPV1.
11. Biosynthesis of capsaicinoids by recombinant Saccharomyces cerevisiae
Sammanfattning : Throughout history, people have used products from different microorganisms and plants for many medicinal and nutritional applications. Chilli peppers have been used for spicing up food, but also for their pharmacological properties. LÄS MER
12. Changes in human uterine innervation in term pregnancy and labor occurence and roles of neurotrophins and TRPV1
Sammanfattning : Objective: Cervical ripening, is a prerequisite for successful labor, which is often very painful and involves an inflammatory reaction. However, little is presently known con-cerning nerve-related changes in the human uterus during labor and the fundamental hy-pothesis tested here was that labor pain emanates primarily from the cervix uteri. LÄS MER
13. Distribution and function of TRP ion channels in primary sensory neurons
Sammanfattning : It is frequently argued that cannabinoids exert part of their analgesic and anti-inflammatory effects via activation of the cannabinoid CB1 receptor located on TRPV1-expressing primary sensory nerve fibres in peripheral tissues. However, we find no evidence of CB1 receptor immunoreactivity on nerve fibres in rat or mouse hindpaw skin and mesenteric artery. LÄS MER
14. Microfluidics based techniques for electrophysiological studies of cells
Sammanfattning : This thesis work investigates the application of microfluidics to perform electrophysiological studies on cells, including investigations of the effect of cholesterol on the dynamic ion permeability of TRPV1 ion channels, and the application of a microfluidic device, the multifunctional pipette, in electrophysiological studies on brain slices. In the first part of this thesis, Chinese hamster ovary (CHO) cells overexpressing the TRPV1 ion channel were used in a dynamic ion permeability study, where the activation properties of the TRPV1 ion channel were investigated using the patch clamp technique after depletion of membrane cholesterol. LÄS MER
15. Signaling Mechanisms in the Neuronal Networks of Pain and Itch
Sammanfattning : Glutamate is the essential neurotransmitters in pain pathways. The discovery of the vesicular glutamate transporters (VGLUT1-3) has been a fundamental step on the way to describe glutamate-dependent pain pathways. We used the Cre-lox system to construct conditional knockouts with deficient Vglut2 transmission in specific neuronal populations. LÄS MER