Sökning: "Peptide"

Visar resultat 31 - 35 av 1718 avhandlingar innehållade ordet Peptide.

1. 31. Apoptosis Regulation via the Mitochondrial Pathway : Membrane Response upon Apoptotic Stimuli

   Författare :Marc-Antoine Sani; Gerhard Grobner; Antoinette Killian; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Apoptosis; BH4 peptide; Bax-α1 peptide; model membrane; cardiolipin; solid phase peptide synthesis; circular dichroism; solid-state nuclear magnetic resonance spectroscopy.; Biophysics; Biofysik;

   Sammanfattning : The aim of this thesis was the investigation of the mitochondrial response mechanisms upon apoptotic stimuli. The specific objectives were the biophysical characterization of membrane dynamics and the specific roles of lipids in the context of apoptotic regulation occurring at the mitochondrion and its complex membrane systems. LÄS MER

3. 32. New Proteomics Methods and Fundamental Aspects of Peptide Fragmentation

   Författare :Mikhail Savitski; Roman Zubarev; Per Andren; David Fenyö; Uppsala universitet; []
   Nyckelord :Bioinformatics; Proteomics; Peptide fragmentation; Bioinformatik;

   Sammanfattning : The combination of collision-activated dissociation, (CAD) and electron capture dissociation, (ECD) yielded a 125% increase in protein identification. The S-score was developed for measuring the information content in MS/MS spectra. This measure made it possible to single out good quality spectra that were not identified by a search engine. LÄS MER

4. 33. NMR studies of the amyloid beta-peptide

   Författare :Jens Danielsson; Astrid Gräslund; Chris Dobson; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NMR; amyloid beta peptide; structure; metal interaction; diffusion; Biophysics; Biofysik;

   Sammanfattning : The Amyloid beta peptide (Ab) is related to Alzheimer’s disease and is suggested to be the molecular pathogenic species of the disease, probably through the neurotoxic effect of Ab oligomers. Here the results from biophysical studies of Ab and fragments thereof, are presented. LÄS MER

5. 34. De Novo Design and Characterization of Surface Binding Peptides - Steps toward Functional Surfaces

   Författare :Patrik Nygren; Bengt-Harald Jonsson; Klas Broo; Linda Andersson; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Peptide; design; nanoparticle; CD; Amino acid; Organic chemistry; Organisk kemi;

   Sammanfattning : The ability to create surfaces with well-defined chemical properties is a major research field. One possibility to do this is to design peptides that bind with a specific secondary structure to silica nanoparticles. LÄS MER

7. 35. Antibody- and Peptide-based Immunotherapies : Proof-of-concept and safety considerations

   Författare :Erika Fletcher; Sara Mangsbo; Vivianne Malmström; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immune complex; conjugat; vaccine; CD40; whole blood; cytokine release syndrome; Immunologi; Immunology;

   Sammanfattning : The aim of cancer immunotherapy is to eradicate tumours by inducing a tumour-specific immune response. This thesis focuses on how antibodies and peptides can improve antigen presentation and the subsequent tumour-specific T cell response. Tumour recognition by the immune system can be promoted through delivery of antigen in the form of a vaccine. LÄS MER