Sökning: "Per Andren"

Visar resultat 1 - 5 av 21 avhandlingar innehållade orden Per Andren.

  1. 1. Improved Neuropeptide Identification : Bioinformatics and Mass Spectrometry

    Författare :Maria Fälth Savitski; Per Andrén; David Fenyö; Per Svenningsson; Ronald Beavis; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; neuropepides; database; peptide identification; peptide fragmentation; mass spectrometry; tandem mass spectromerty; Bioinformatics; Bioinformatik;

    Sammanfattning : Bioinformatic methods were developed for improved identification of endogenous peptides using mass spectrometry. As a framework for these methods, a database for endogenous peptides, SwePep, was created. It was designed for storing information about endogenous peptides including tandem mass spectra. LÄS MER

  3. 2. Development and Application of Software Tools for Mass Spectrometry Imaging

    Författare :Patrik Källback; Per E. Andrén; Per Svenningsson; Anna Nilsson; Benjamin Bowen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry imaging; MALDI; DESI; msIQuant; quantitation; neurotransmitters; drugs; derivatization; brain; compression; data entropy reduction;

    Sammanfattning : Mass spectrometry imaging (MSI) has been extensively used to produce qualitative maps of distributions of proteins, peptides, lipids, neurotransmitters, small molecule pharmaceuticals and their metabolites directly in biological tissue sections. Moreover, during the last 10 years, there has been growing demand to quantify target compounds in tissue sections of various organs. LÄS MER

  4. 3. Neuropeptidomics – Methods and Applications

    Författare :Karl Sköld; Per E Andrén; Per Svenningsson; Chris Shaw; Uppsala universitet; []
    Nyckelord :Pharmaceutical pharmacology; mass spectrometry; proteomics; peptidomics; neuropeptide; bioinformatics; Farmaceutisk farmakologi;

    Sammanfattning : The sequencing of genomes has caused a growing demand for functional analysis of gene products. This research field named proteomics is derived from the term proteome, which by analogy to genome is defined as all proteins expressed by a cell or a tissue. LÄS MER

  5. 4. Neuropeptidomics – Expanding Proteomics Downwards

    Författare :Marcus Svensson; Per Andrén; Per Svenningsson; Jonathan Sweedler; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical pharmacology; proteomics; peptidomics; mass spectrometry; neuropeptide; chromatography; Farmaceutisk farmakologi; PHARMACY; FARMACI;

    Sammanfattning : Biological function is mainly carried out by a dynamic population of proteins which may be used as markers for disease diagnosis, prognosis, and as a guide for effective treatment. In analogy to genomics, the study of proteins is called proteomics and it is generally performed by two-dimensional gel electrophoresis and mass spectrometric methods. LÄS MER

  7. 5. Improving access to behaviour therapy for young people with Tourette syndrome

    Författare :Per Andrén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tourette syndrome (TS) and Chronic Tic Disorder (CTD) are childhood-onset neurodevelopmental disorders characterised by motor and vocal tics. Treatment guidelines recommend behaviour therapy (BT) as the first-line treatment for TS/CTD, but availability is generally low. LÄS MER