Sökning: "Mouse embryo"

Visar resultat 1 - 5 av 68 avhandlingar innehållade orden Mouse embryo.

1. 1. Fetal Outcome in Experimental Diabetic Pregnancy

   Författare :Sheller Zabihi; Ulf Eriksson; Michael Welsh; Elisabeth (Lisa) Persson; Uppsala universitet; []
   Nyckelord :Cell biology; Rat; Mouse; TG; KO; Diabetes in Pregnancy; Embryo; Folic acid; Superoxide dismutase; Catalase; Glutathione peroxidase; Vascular endothelial growth factor-A; Folate binding protein-1; Bax; Bcl-2; Caspase-3; P53; Pax-3; Blood flow; Cellbiologi;

   Sammanfattning : Women with pregestational diabetes have a 2-5 fold increased risk of giving birth to malformed babies compared with non-diabetic women. Diabetes-induced oxidative stress in maternal and embryonic tissues has been implicated in the teratogenic process. LÄS MER

3. 2. Mechanisms controlling striatal projection neurone generation, from patterning to early differentiation

   Författare :Håkan Toresson; Klinisk minnesforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pbx; meis; sonic hedgehog; small eye; pax6; gsh2; gsh1; cerebral cortex; striatum; telencephalon; mutant; development; mouse; embryo; retinoic acid; Clinical biology; Klinisk biologi;

   Sammanfattning : The striatum is part of the telencephalon, the most anterior part of the vertebrate brain. From when it first can be identified, telencephalic morphology is highly complex and a wide range of mechanisms has been suggested to participate in its induction, patterning and neurogenesis. LÄS MER

4. 3. Stochastic modelling and analysis of early mouse development

   Författare :Sofia Tapani; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; correlation; CUSUM; mouse; non-stationarity; pronucleus; stochastic differential equation; time series; wavelet decomposition; yeast; CUSUM;

   Sammanfattning : The aim of this thesis is to model and describe dynamical events for biological cells using statistical and mathematical tools. The thesis includes five papers that all relate to stochastic modelling of cells. LÄS MER

5. 4. Molecular and Cellular Control of Palate Development in the Mouse

   Författare :Forugh Vazirisani; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cleft palate; fate mapping; Sonic hedgehog; apoptosis; extracellular matrix; mouse;

   Sammanfattning : The formation of a definitive secondary palate in mammals is a multistep process that comprises growth, elevation, contact and fusion of the two palatal shelves. Disruption at any step generates cleft palate, a major congenital birth defect. Therefore, it is important to understand the mechanisms governing normal palate development. LÄS MER

7. 5. Transcriptomics and Proteomics Applied to Developmental Toxicology

   Författare :Kim Kultima; Lennart Dencker; Timothy Gant; Uppsala universitet; []
   Nyckelord :Toxicology; 2D-DIGE; Valproic acid; PBDE-99; Flame retardant; Neural tube defects; Microarray; In vivo; In vitro; Biomarker; Brain growth spurt; Normalization; Mouse embryo; Toxicogenomics; Toxikologi;

   Sammanfattning : Developmental toxicology is an important part of preclinical drug toxicology as well as environmental toxicology. Assessing reproductive and developmental toxicity is especially expensive and time demanding, since at least two generations of animals are needed in the tests. LÄS MER