Sökning: "Vascular endothelial growth factor-A"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden Vascular endothelial growth factor-A.

  1. 1. Vascular Endothelial Growth Factor (VEGF) and Peripheral Nerve Regeneration

    Författare :Mariann Sondell; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Schwann cell; SCG; rat; peripheral nerve regeneration; neuropilin-1; nerve repair; mouse; growth factor; flk-1; axonal outgrowth; DRG; VEGF; Animal physiology; Djurfysiologi;

    Sammanfattning : This thesis concerns vascular endothelial growth factor (VEGF) and its possible role as a neurotrophic factor. I have investigated the effect of VEGF on neurons in culture but also in vivo, following a crush lesion of the sciatic nerve, and following nerve repair. LÄS MER

  3. 2. Tamoxifen response in primary breast cancer with special reference to tumour-specific VEGF-A and VEGFR2

    Författare :Lisa Rydén; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytology; oncology; cancerology; Cytologi; onkologi; cancer; prognosis; randomised controlled trial; adjuvant tamoxifen treatment; vascular endothelial growth factor receptor 2; breast cancer; vascular endothelial growth factor A;

    Sammanfattning : Background: Treatment of primary breast cancer is individualised and adjuvant systemic treatment is delivered to most patients after surgery. Oestrogen receptor (ER) status and progesterone receptor status (PR) can define patients who would benefit from adjuvant endocrine therapy with tamoxifen (TAM) alone or as chemo-endocrine therapy. LÄS MER

  4. 3. New Roles of Filamins in Cell Signaling, Transcription and Organ Development

    Författare :Xianghua Zhou; Göteborgs universitet; []
    Nyckelord :filamins; cell movement; hypoxia-inducible factor 1; proto-oncogene proteins c-met; mice; knockout; F-actin-binding proteins; integrins; GTB phosphohydrolases; genetic diseases; inborn; vascular endothelial cell growth factor A; Smad2 protein; hepatocyte growth factor; cartilage; osteogenesis; neovascularization; neoplasm metastasis;

    Sammanfattning : Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin networks and link them to cellular membranes. They integrate cell architectural and signaling functions and are essential for cell locomotion and development. LÄS MER

  5. 4. Fetal Outcome in Experimental Diabetic Pregnancy

    Författare :Sheller Zabihi; Ulf Eriksson; Michael Welsh; Elisabeth (Lisa) Persson; Uppsala universitet; []
    Nyckelord :Cell biology; Rat; Mouse; TG; KO; Diabetes in Pregnancy; Embryo; Folic acid; Superoxide dismutase; Catalase; Glutathione peroxidase; Vascular endothelial growth factor-A; Folate binding protein-1; Bax; Bcl-2; Caspase-3; P53; Pax-3; Blood flow; Cellbiologi;

    Sammanfattning : Women with pregestational diabetes have a 2-5 fold increased risk of giving birth to malformed babies compared with non-diabetic women. Diabetes-induced oxidative stress in maternal and embryonic tissues has been implicated in the teratogenic process. LÄS MER

  7. 5. Molecular Mechanisms in Endothelial Cell Differentiation

    Författare :Emma Rennel; Pär Gerwins; Lena Claesson-Welsh; Ian Zachary; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; angiogenesis; FGF-2; VEGF-A; signal transduction; in vitro angiogenesis assay; immortalized brain endothelial cells; H-Ras; tetracycline-regulated gene expression; microarray; telomerase immortalized human microvascular endothelial cells; differentiation; Patologi; Pathology; Patologi;

    Sammanfattning : Angiogenesis is the formation of new blood vessels from the pre-existing blood vessels. Blood vessels are composed of endothelial cells and supporting musculature. Angiogenesis is regulated by numerous soluble ligands and by cell-matrix interactions. LÄS MER