Sökning: "PBDE-99"

Hittade 4 avhandlingar innehållade ordet PBDE-99.

  1. 1. Transcriptomics and Proteomics Applied to Developmental Toxicology

    Författare :Kim Kultima; Lennart Dencker; Timothy Gant; Uppsala universitet; []
    Nyckelord :Toxicology; 2D-DIGE; Valproic acid; PBDE-99; Flame retardant; Neural tube defects; Microarray; In vivo; In vitro; Biomarker; Brain growth spurt; Normalization; Mouse embryo; Toxicogenomics; Toxikologi;

    Sammanfattning : Developmental toxicology is an important part of preclinical drug toxicology as well as environmental toxicology. Assessing reproductive and developmental toxicity is especially expensive and time demanding, since at least two generations of animals are needed in the tests. LÄS MER

  3. 2. Proteomic Characterization of Induced Developmental Neurotoxicity

    Författare :Henrik Alm; Lennart Dencker; R Stuart Cobb; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteomics; Brain Development; Neurotoxicity; 2D-DIGE; Brain Growth Spurt; Polybrominated Diphenyl Ether; Neonatal; Striatum; Hippocampus; Cerebral Cortex; Parkinsonism; Dyskinesia; Toxicology; Toxikologi; Toxicology; Toxikologi;

    Sammanfattning : The developing brain goes through a number of developmental periods during which it displays an increased sensitivity to exogenous disturbances. On such period is the so called “Brain growth spurt” (BGS) which in humans takes place starting from the third trimester of pregnancy and throughout the first few years of life. LÄS MER

  4. 3. Developmental Neurotoxicity in Mice Neonatally Co-exposed to Environmental Agents : PCB, PBDE, Methyl Mercury and Ionized Radiation - Interactions and Effects

    Författare :Celia Fischer; Per Eriksson; Anders Fredriksson; Richard Seegal; Uppsala universitet; []
    Nyckelord :Biology; PCB; PBDE; MeHg; ionized radiation; neonatal; development; neurotoxicity; behavior; cholinergic system; Biologi;

    Sammanfattning : This thesis investigates the neurotoxic effects in mice neonatally co-exposed to different toxic environmental agents during a defined critical period of the brains's rapid growth and development. Environmental toxic agents are incorporated in our environment. LÄS MER

  5. 4. Neonatal Developmental Neurotoxicity of Brominated Flame Retardants, the Polybrominated Diphenyl Ethers (PBDEs)

    Författare :Henrik Viberg; Per Eriksson; Susan Schantz; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; brominated flame retardants; polybrominated diphenyl ethers; PBDE; neonatal; development; neurotoxicity; behaviour; cholinergic system; Biologi; Biology; Biologi;

    Sammanfattning : This thesis examines developmental neurotoxic effects of polybrominated diphenyl ethers (PBDEs), PBDE 99, PBDE 153, and the fully brominated PBDE 209, after exposure during the newborn period in rodents. Our environment contains vast numbers of contaminants, including the flame retardants, PBDEs. LÄS MER