Sökning: "Immunotherapy"

Visar resultat 26 - 30 av 288 avhandlingar innehållade ordet Immunotherapy.

1. 26. Antibody-based Cancer Immunotherapy : Personalization, response prediction and safety considerations

   Författare :Mohamed Eltahir; Sara Mangsbo; Patrick Micke; Gustav Ullenhag; Marit Inderberg; Uppsala universitet; []
   Nyckelord :;

   Sammanfattning : Antibody-based therapeutics have remarkably improved the field of immuno-oncology. Multiple monoclonal antibodies (mAbs) are approved for clinical use, and numerous antibodies are under clinical development. The scope of this thesis is to study the personalization of antibody-based immunotherapeutics and tools to predict their efficacy and safety. LÄS MER

3. 27. CAR T cells for Immunotherapy of Cancer

   Författare :Tina Sarén; Magnus Essand; Martin Pule; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chimeric antigen receptor CAR -T cells; Cancer immunotherapy; NAP; Tonic signaling; T cell exhaustion; B cell lymphoma; clinical trial; glioblastoma;

   Sammanfattning : In recent years, immunotherapy has revolutionized cancer treatment by prolonging survival and even curing patients lacking other available therapies. Besides immune checkpoint inhibitors, one of the major advances is attributed to the success of chimeric antigen receptor (CAR)-T cell therapy in treating patients with B-cell malignancies. LÄS MER

4. 28. Allogeneic dendritic cells as adjuvants in cancer immunotherapy

   Författare :Grammatiki Fotaki; Magnus Essand; Alex Karlsson-Parra; Di Yu; Tanja de Gruijl; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allogeneic dendritic cells; immune primer; adjuvant; adenoviral vector; cancer immunotherapy; tumor microenvironment; Klinisk immunologi; Clinical Immunology;

   Sammanfattning : In recent years, immunotherapeutic approaches have achieved remarkable successes through checkpoint blockade antibodies, advances in the use of chimeric antigen receptor (CAR) T cells and new insights into the immunosuppressive role of the tumor microenvironment (TME). Through the advances, the role of cancer vaccines based on ex vivo manipulated autologous dendritic cells (DC) has been challenged. LÄS MER

5. 29. Immunotherapy in cancer and HIV

   Författare :Susanne Johansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Immunotherapy; Cancer; HIV; DNA-vaccine; Conjugated mAb; NK-cells;

   Sammanfattning : Two major threats to human health are cancer and human immunodeficiency virus (HIV) infection. In both cases, a feature of progress of the disease is a defective immune function. Immunological mechanisms have evolved whereby transformed cells and HIV-1 infected cells avoid recognition and elimination by the immune system. LÄS MER

7. 30. Novel approaches for cancer immunotherapy

   Författare :Fredrik Eriksson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cancer immunotherapy, i.e. activation of the patient s own immune system to combat cancer, represents a treatment strategy which is being clinically tested to complement surgery, radiotherapy and chemotherapy the current cornerstones of our fight against cancer. LÄS MER