Sökning: "T cell exhaustion"

Visar resultat 1 - 5 av 24 avhandlingar innehållade orden T cell exhaustion.

1. 1. CD19-targeting CAR T Cells for Treatment of B Cell Malignancies : From Bench to Bedside

   Författare :Hannah Karlsson; Angelica Loskog; Karl-Johan Malmberg; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; chimeric antigen receptors; CAR T cells; T cell therapy; immunotherapy; CD19; Bcl-2 family inhibitors; B cell malignancies; Klinisk immunologi; Clinical Immunology;

   Sammanfattning : Immunotherapy for cancer is a young research field progressing at high speed. The first chimera of an antibody and a signaling chain was designed by Zelig Eshhar and was later further developed to enhance existing T cell therapy by combining a single-chain fragment of an antibody with the CD3 zeta chain of the TCR complex. LÄS MER

3. 2. CAR T cells for Immunotherapy of Cancer

   Författare :Tina Sarén; Magnus Essand; Martin Pule; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chimeric antigen receptor CAR -T cells; Cancer immunotherapy; NAP; Tonic signaling; T cell exhaustion; B cell lymphoma; clinical trial; glioblastoma;

   Sammanfattning : In recent years, immunotherapy has revolutionized cancer treatment by prolonging survival and even curing patients lacking other available therapies. Besides immune checkpoint inhibitors, one of the major advances is attributed to the success of chimeric antigen receptor (CAR)-T cell therapy in treating patients with B-cell malignancies. LÄS MER

4. 3. Potential immunoregulatory role of T and dendritic cells in cancer : Investigations based on transcriptional analysis

   Författare :Milad Abolhalaj; Institutionen för immunteknologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dendritic cells; T cells; head and neck cancer; acute myeloid leukemia; bladder cancer; T cell exhaustion;

   Sammanfattning : Cancer is a complex disease with various genetic and epigenetic driving factors. Cancer cells form a favored microenvironment to sustain their uncontrolled behavior leading to abnormal growth. With standard treatment including chemotherapy, relapse risk is high due to the resistance that cancer cells can develop against chemotherapy agents. LÄS MER

5. 4. Single cell studies of human T cell function with applications for HIV-1

   Författare :Johanna Tauriainen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : T cells are one of the body’s main defenses against viruses and cancers and are therefore considered to play a major role in immunotherapies after stem cell transplantation and in HIV-1 vaccine and cure strategies. However, malignancies and chronic viral infections, such as HIV-1, eventually cause the T cells to become dysfunctional, resulting in a loss of control. LÄS MER

7. 5. Immune deterioration in HIV-1 and HIV-2 infection with a focus on CD8 T cell exhaustion

   Författare :Lydia Scharf; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Thanks to the development of antiretroviral treatment (ART), human immunodeficiency virus (HIV) infection is now considered a chronic infection rather than the death sentence it used to be. Despite constant expansion and improvement of treatment options, even optimal therapy cannot prevent the impact of HIV on the human immune system. LÄS MER