Sökning: "Di Yu"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Di Yu.

  1. 1. Adenovirus for Cancer Therapy : With a Focus on its Surface Modification

    Författare :Di Yu; Magnus Essand; Dirk Nettelbeck; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adenovirus; cancer; therapy; neuroblastoma; neuroendocrine; modification; Tat; PTD; cell penetrating peptide; Helicobacter pylori; NAP; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Klinisk virologi; Clinical Virology; Medical Virology; Medicinsk virologi; Molekylär medicin; Molecular Medicine; Molekylär bioteknik; Molecular Biotechnology;

    Sammanfattning : Adenovirus serotype 5 (Ad5) is widely used as an oncolytic agent for cancer therapy. However, its infectivity is highly dependent on the expression level of coxsackievirus-adenovirus receptor (CAR) on the surface of tumor cells. LÄS MER

  3. 2. Allogeneic dendritic cells as adjuvants in cancer immunotherapy

    Författare :Grammatiki Fotaki; Magnus Essand; Alex Karlsson-Parra; Di Yu; Tanja de Gruijl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allogeneic dendritic cells; immune primer; adjuvant; adenoviral vector; cancer immunotherapy; tumor microenvironment; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : In recent years, immunotherapeutic approaches have achieved remarkable successes through checkpoint blockade antibodies, advances in the use of chimeric antigen receptor (CAR) T cells and new insights into the immunosuppressive role of the tumor microenvironment (TME). Through the advances, the role of cancer vaccines based on ex vivo manipulated autologous dendritic cells (DC) has been challenged. LÄS MER

  4. 3. Flood Hazard Assessment in Data-Scarce Basins : Use of alternative data and modelling techniques

    Författare :Diana Fuentes-Andino; Sven Halldin; Chong-Yu Xu; Keith Beven; Giuliano Di Baldassarre; Wouter Buytaert; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Central America; floods; data scarcity; data quality; uncertainty analysis; regionalisation; flood frequency analysis; GLUE; hydraulic modelling; rainfall-runoff modeling; TOPMODEL; LISFLOOD-FP; GRADEX; index-flood; Muskingum-Cunge-Todini flow routing; Mellanamerika; högflöde; datakvalitet; osäkerhetsanalys; regionalisering; frekvensanalys av högflöden; GLUE; hydraulisk modellering; nederbörds-avrinningsmodeller; TOPMODEL; LISFLOOD-FP; GRADEX; indexflöde; Muskingum-Cunge-Todini flödessvarstid; Central América; inundaciones; escasez de datos; calidad de los datos; análisis de incertidumbre; regionalización; análisis de frequencia de inundación; GLUE; modelación hidraulica; modelo de lluvia-escorrentía; TOPMODEL; LISFLOOD-FP; GRADEX; índice de inundación; Muskingum-Cunge-Todini rutina de propagación de flujo;

    Sammanfattning : Flooding is of great concern world-wide, causing damage to infrastructure, property and loss of life. Low-income countries, in particular, can be negatively affected by flood events due to their inherent vulnerabilities. Moreover, data to perform studies for flood risk management in low-income regions are often scarce or lacking sufficient quality. LÄS MER

  5. 4. Cancer Immunotherapy : Oncolytic viruses and CAR-T cells

    Författare :Jing Ma; Di Yu; Magnus Essand; Mia Phillipson; Mohanraj Ramachandran; Karl-Johan Malmberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer immunotherapy; Oncolytic viruses; chimeric antigen receptor CAR -T cells; Helicobacter pylori Neutrophil Activating Protein;

    Sammanfattning : Various forms of cancer immunotherapy have developed rapidly with improved survival and quality of life for cancer patients. Cancer immunotherapy aims to educate the patient’s immune system to eliminate cancer cells, including immune checkpoint inhibitors (ICIs), adoptive cell transfer (mostly T cells), oncolytic viruses (OVs) and cancer vaccines. LÄS MER

  7. 5. Cancer Immunotherapy : Evolving Oncolytic viruses and CAR T-cells

    Författare :Mohanraj Ramachandran; Magnus Essand; Di Yu; Justyna Leja-Jarblad; Richard Vile; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncolytic virus; Adenovirus; Semliki Forest virus; Cancer immunology; Chimeric antigen receptor T-cells; Immunologi; Immunology; Oncology; Onkologi; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : In the last decade cancer immunotherapy has taken huge strides forward from bench to bedside and being approved as drugs. Cancer immunotherapy harnesses the power of patient’s own immune system to fight cancer. LÄS MER