Sökning: "Alex Karlsson-Parra"

Hittade 4 avhandlingar innehållade orden Alex Karlsson-Parra.

  1. 1. Lymphoid cell phenotyping in autoimmunity : a methodological and clinical study

    Författare :Alex Karlsson-Parra; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  3. 2. Allogeneic dendritic cells as adjuvants in cancer immunotherapy

    Författare :Grammatiki Fotaki; Magnus Essand; Alex Karlsson-Parra; Di Yu; Tanja de Gruijl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allogeneic dendritic cells; immune primer; adjuvant; adenoviral vector; cancer immunotherapy; tumor microenvironment; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : In recent years, immunotherapeutic approaches have achieved remarkable successes through checkpoint blockade antibodies, advances in the use of chimeric antigen receptor (CAR) T cells and new insights into the immunosuppressive role of the tumor microenvironment (TME). Through the advances, the role of cancer vaccines based on ex vivo manipulated autologous dendritic cells (DC) has been challenged. LÄS MER

  4. 3. Autoantibodies and genetic variation in rheumatoid arthritis : aspects on susceptibility and disease course

    Författare :Alf Kastbom; Thomas Skogh; Peter Söderkvist; Alex Karlsson-Parra; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; autoantibodies; single-nucleotide polymorphisms; disease course; Rheumatology; Reumatologi;

    Sammanfattning : Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and subsequent destruction of synovial joints. Although its causes remain largely unknown, a substantial genetic contribution is known to exist. LÄS MER

  5. 4. On CD4+ T Lymphocytes in Solid Tumours

    Författare :Per Marits; Ola Winqvist; Magnus Thörn; Alex Karlsson-Parra; Uppsala universitet; []
    Nyckelord :Molecular medicine; Tumour immunology; T lymphocytes; sentinel node detection; colon cancer; urinary bladder cancer; adoptive immunotherapy; Molekylärmedicin;

    Sammanfattning : This thesis deals with recognition and elimination of tumours by T lymphocytes and their use in adoptive immunotherapy.The first tumour-draining lymph node; the sentinel node, is identified by peritumoural injection of a tracer. This is the hypothesised location for the activation of tumour-reactive lymphocytes. LÄS MER